12(S)-HPETE induces itch-associated scratchings in mice

Dae Kwon Kim; Hyung June Kim; Ki Sa Sung; Hyuk Kim; Sun A. Cho; Kwang Mi Kim; Chang Hoon Lee; Jung Ju Kim

doi:10.1016/j.ejphar.2006.09.057

12(S)-HPETE induces itch-associated scratchings in mice

Dae Kwon Kim, Hyung June Kim, Ki Sa Sung, Hyuk Kim, Sun A. Cho, Kwang Mi Kim, Chang Hoon Lee, Jung Ju Kim

Department of Pharmacy

Amorepacific Corporation

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The itch-associated responses evoked by intradermal injection of 12(S)-HPETE and leukotriene B₄ were compared in ICR-mice. 12(S)-HPETE and leukotriene B₄ (0.01-0.2 nmol/site) induced scratching of the injected site, respectively; the dose-responses were a peak at 0.05 nmol/site (12(S)-HPETE) or 0.03 nmol/site (leukotriene B₄). The scratching response by 12(S)-HPETE (0.05 nmol/site) started within 1 min, peaked in the first 10 min period, had almost subsided by 25 min whereas the effect of leukotriene B₄ peaked in the second 10 min. The effect of leukotriene B₄ is slightly stronger than that of 12(S)-HPETE in 40 min of count. The scratching induced by 12(S)-HPETE was inhibited by capsaicin, naltrexon, and LY255283. These results suggest the possibility that 12-lipoxygenase product can be added to a new member of an endogenous itch mediator in the skin.

Original language	English
Pages (from-to)	30-33
Number of pages	4
Journal	European Journal of Pharmacology
Volume	554
Issue number	1
DOIs	https://doi.org/10.1016/j.ejphar.2006.09.057
State	Published - 5 Jan 2007

Keywords

12(S)-HPETE
Intradermal injection 12-lipoxygenase
Itch
Leukotriene B
Scratching

Access to Document

10.1016/j.ejphar.2006.09.057

Cite this

@article{f7f8bf45be0c41a2af9cd3b4d4d51706,

title = "12(S)-HPETE induces itch-associated scratchings in mice",

abstract = "The itch-associated responses evoked by intradermal injection of 12(S)-HPETE and leukotriene B4 were compared in ICR-mice. 12(S)-HPETE and leukotriene B4 (0.01-0.2 nmol/site) induced scratching of the injected site, respectively; the dose-responses were a peak at 0.05 nmol/site (12(S)-HPETE) or 0.03 nmol/site (leukotriene B4). The scratching response by 12(S)-HPETE (0.05 nmol/site) started within 1 min, peaked in the first 10 min period, had almost subsided by 25 min whereas the effect of leukotriene B4 peaked in the second 10 min. The effect of leukotriene B4 is slightly stronger than that of 12(S)-HPETE in 40 min of count. The scratching induced by 12(S)-HPETE was inhibited by capsaicin, naltrexon, and LY255283. These results suggest the possibility that 12-lipoxygenase product can be added to a new member of an endogenous itch mediator in the skin.",

keywords = "12(S)-HPETE, Intradermal injection 12-lipoxygenase, Itch, Leukotriene B, Scratching",

author = "Kim, {Dae Kwon} and Kim, {Hyung June} and Sung, {Ki Sa} and Hyuk Kim and Cho, {Sun A.} and Kim, {Kwang Mi} and Lee, {Chang Hoon} and Kim, {Jung Ju}",

year = "2007",

month = jan,

day = "5",

doi = "10.1016/j.ejphar.2006.09.057",

language = "English",

volume = "554",

pages = "30--33",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - 12(S)-HPETE induces itch-associated scratchings in mice

AU - Kim, Dae Kwon

AU - Kim, Hyung June

AU - Sung, Ki Sa

AU - Kim, Hyuk

AU - Cho, Sun A.

AU - Kim, Kwang Mi

AU - Lee, Chang Hoon

AU - Kim, Jung Ju

PY - 2007/1/5

Y1 - 2007/1/5

N2 - The itch-associated responses evoked by intradermal injection of 12(S)-HPETE and leukotriene B4 were compared in ICR-mice. 12(S)-HPETE and leukotriene B4 (0.01-0.2 nmol/site) induced scratching of the injected site, respectively; the dose-responses were a peak at 0.05 nmol/site (12(S)-HPETE) or 0.03 nmol/site (leukotriene B4). The scratching response by 12(S)-HPETE (0.05 nmol/site) started within 1 min, peaked in the first 10 min period, had almost subsided by 25 min whereas the effect of leukotriene B4 peaked in the second 10 min. The effect of leukotriene B4 is slightly stronger than that of 12(S)-HPETE in 40 min of count. The scratching induced by 12(S)-HPETE was inhibited by capsaicin, naltrexon, and LY255283. These results suggest the possibility that 12-lipoxygenase product can be added to a new member of an endogenous itch mediator in the skin.

AB - The itch-associated responses evoked by intradermal injection of 12(S)-HPETE and leukotriene B4 were compared in ICR-mice. 12(S)-HPETE and leukotriene B4 (0.01-0.2 nmol/site) induced scratching of the injected site, respectively; the dose-responses were a peak at 0.05 nmol/site (12(S)-HPETE) or 0.03 nmol/site (leukotriene B4). The scratching response by 12(S)-HPETE (0.05 nmol/site) started within 1 min, peaked in the first 10 min period, had almost subsided by 25 min whereas the effect of leukotriene B4 peaked in the second 10 min. The effect of leukotriene B4 is slightly stronger than that of 12(S)-HPETE in 40 min of count. The scratching induced by 12(S)-HPETE was inhibited by capsaicin, naltrexon, and LY255283. These results suggest the possibility that 12-lipoxygenase product can be added to a new member of an endogenous itch mediator in the skin.

KW - 12(S)-HPETE

KW - Intradermal injection 12-lipoxygenase

KW - Itch

KW - Leukotriene B

KW - Scratching

UR - http://www.scopus.com/inward/record.url?scp=33751415591&partnerID=8YFLogxK

U2 - 10.1016/j.ejphar.2006.09.057

DO - 10.1016/j.ejphar.2006.09.057

M3 - Article

C2 - 17112507

AN - SCOPUS:33751415591

SN - 0014-2999

VL - 554

SP - 30

EP - 33

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

12(S)-HPETE induces itch-associated scratchings in mice

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this