2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

Song Seok Shin; Min Soo Noh; Young Joo Byun; Jin Kyu Choi; Ji Young Kim; Kyung Min Lim; Jun Yong Ha; Jin Kwan Kim; Chang Hoon Lee; Shin Chung

doi:10.1016/S0960-894X(00)00634-X

2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

Song Seok Shin
, Min Soo Noh
, Young Joo Byun
, Jin Kyu Choi
, Ji Young Kim
, Kyung Min Lim
, Jun Yong Ha
, Jin Kwan Kim
, Chang Hoon Lee
, Shin Chung

Department of Pharmacy

Amorepacific Corporation

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A series of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(00)00634-X
State	Published - 22 Jan 2001

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title = "2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors",

abstract = "A series of 2,2-dimethyl-5-\{4-(methylsulfonyl)phenyl\}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).",

author = "Shin, \{Song Seok\} and Noh, \{Min Soo\} and Byun, \{Young Joo\} and Choi, \{Jin Kyu\} and Kim, \{Ji Young\} and Lim, \{Kyung Min\} and Ha, \{Jun Yong\} and Kim, \{Jin Kwan\} and Lee, \{Chang Hoon\} and Shin Chung",

year = "2001",

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doi = "10.1016/S0960-894X(00)00634-X",

language = "English",

volume = "11",

pages = "165--168",

journal = "Bioorganic and Medicinal Chemistry Letters",

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publisher = "Elsevier Ltd",

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T1 - 2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

AU - Shin, Song Seok

AU - Noh, Min Soo

AU - Byun, Young Joo

AU - Choi, Jin Kyu

AU - Kim, Ji Young

AU - Lim, Kyung Min

AU - Ha, Jun Yong

AU - Kim, Jin Kwan

AU - Lee, Chang Hoon

AU - Chung, Shin

PY - 2001/1/22

Y1 - 2001/1/22

N2 - A series of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).

AB - A series of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).

UR - https://www.scopus.com/pages/publications/0035931560

U2 - 10.1016/S0960-894X(00)00634-X

DO - 10.1016/S0960-894X(00)00634-X

M3 - Article

C2 - 11206450

AN - SCOPUS:0035931560

SN - 0960-894X

VL - 11

SP - 165

EP - 168

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

2,2-dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

Abstract

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