4’-O-β-D-glucosyl-5-O-methylvisamminol attenuates pro-inflammatory responses and protects against oxidative damages

Ok Kyung Yoo, Young Sam Keum

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We attempted to examine anti-inflammatory and anti-oxidant effects of 4’-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage RAW 264.7 cells, it significantly suppressed lipopolysaccharide (LPS)-induced generation of prostaglandin E2 (PGE2) and nitric oxide (NO) through transcriptional inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). GOMV also scavenged free radicals in vitro, increased NF-E2-related factor 2 (NRF2), and activated antioxidant response element (ARE), thereby resulting in the induction of phase II cytoprotective enzymes in human keratinocyte HaCaT cells. Finally, GOMV significantly protected HaCaT cells against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative intracellular damages. Together, our results illustrate that GOMV possesses anti-inflammatory and anti-oxidant activity.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalBiomolecules and Therapeutics
Volume27
Issue number4
DOIs
StatePublished - 2019

Keywords

  • 4’-O-β-D-glucosyl-5-O-methylvisamminol (GOMV)
  • Antioxidant response element (ARE)
  • NF-E2-related factor 2 (NRF2)
  • Reactive oxygen species (ROS)

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