A case of acute aortic thrombosis after cisplatin-based chemotherapy

Suk Jae Hahn, Jin Young Oh, Jeung Sook Kim, Do Yeun Kim

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11 Scopus citations

Abstract

Cisplatin-based therapy is associated with various toxicities, including renal failure and neuropathy. However, acute arterial thrombosis is also a possible toxic effect of cisplatin, one that has been documented in a few cases worldwide. Here we present a rare case of ascending aortic thrombosis occurring 9 days after cisplatin-based chemotherapy in a 74-year-old male who was diagnosed with malignant pleural effusion suggestive of non-small cell lung cancer. The patient did not have any predisposing factor for the occurrence of an aortic thrombus before cisplatin-based chemotherapy. Thus, we suggest that the hypercoagulable state occurred secondary to cisplatin-based chemotherapy and was additive to the malignancy itself, causing aortic thrombosis. The patient was treated successfully with low-molecular-weight heparin and warfarin.

Original languageEnglish
Pages (from-to)732-736
Number of pages5
JournalInternational Journal of Clinical Oncology
Volume16
Issue number6
DOIs
StatePublished - Dec 2011

Keywords

  • Aorta
  • Cisplatin
  • Thrombosis

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