Abstract
Cisplatin-based therapy is associated with various toxicities, including renal failure and neuropathy. However, acute arterial thrombosis is also a possible toxic effect of cisplatin, one that has been documented in a few cases worldwide. Here we present a rare case of ascending aortic thrombosis occurring 9 days after cisplatin-based chemotherapy in a 74-year-old male who was diagnosed with malignant pleural effusion suggestive of non-small cell lung cancer. The patient did not have any predisposing factor for the occurrence of an aortic thrombus before cisplatin-based chemotherapy. Thus, we suggest that the hypercoagulable state occurred secondary to cisplatin-based chemotherapy and was additive to the malignancy itself, causing aortic thrombosis. The patient was treated successfully with low-molecular-weight heparin and warfarin.
Original language | English |
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Pages (from-to) | 732-736 |
Number of pages | 5 |
Journal | International Journal of Clinical Oncology |
Volume | 16 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2011 |
Keywords
- Aorta
- Cisplatin
- Thrombosis