A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss

Gun Hee Yu, Yong Jun Choi, Hahn Jin Jung, Yun Sung Lim, Seok Won Park, Chang Gun Cho, Joo Hyun Park

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Introduction: Glucocorticoids are considered the first-line therapy for sudden sensorineural hearing loss. But there is currently no consensus on administering them as a single dose versus multiple divided daily doses. Objective: We aim to evaluate the treatment outcome of sudden sensorineural hearing loss between a single-dose and multiple divided daily doses of steroid treatment. Methods: A total of 94 patients who were diagnosed and treated for sudden sensorineural hearing loss and followed up for more than three months were reviewed retrospectively. Patients were divided into single-dose and multiple divided-dose groups, based on their medication regimens. Hearing thresholds were repeatedly measured: on the initial visit and 1 week, 1 month, and 3 months after the initial treatment. Treatment outcomes were analyzed by comparing hearing recovery rates and post-treatment audiometric changes. Results: The hearing threshold was significantly reduced at three months post-treatment in both groups. The hearing recovery rate of the single-dose group was significantly higher than that of the multiple divided-dose groups. Audiometric changes showed no statistical difference either in pure tone threshold or speech discrimination. Conclusion: When oral steroids are indicated for sudden sensorineural hearing loss, both a single dose and multiple divided doses can be effective for treatment and have comparable results. However, the single-dose regimen seems to be more efficacious than the divided-dose regimen.

Original languageEnglish
Pages (from-to)733-738
Number of pages6
JournalBrazilian Journal of Otorhinolaryngology
Volume85
Issue number6
DOIs
StatePublished - 1 Nov 2019

Keywords

  • Dose
  • Regimen
  • Steroid
  • Sudden sensorineural hearing loss

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