TY - JOUR
T1 - A comprehensive overview on the production of vaccines in plant-based expression systems and the scope of plant biotechnology to combat against sars-cov-2 virus pandemics
AU - Kumar, Manu
AU - Kumari, Nisha
AU - Thakur, Nishant
AU - Bhatia, Shashi Kant
AU - Saratale, Ganesh Dattatraya
AU - Ghodake, Gajanan
AU - Mistry, Bhupendra M.
AU - Alavilli, Hemasundar
AU - Kishor, D. S.
AU - Du, Xueshi
AU - Chung, Sang Min
N1 - Publisher Copyright:
Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6
Y1 - 2021/6
N2 - Many pathogenic viral pandemics have caused threats to global health; the COVID-19 pandemic is the latest. Its transmission is growing exponentially all around the globe, putting constraints on the health system worldwide. A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes this pandemic. Many candidate vaccines are available at this time for COVID-19, and there is a massive international race underway to procure as many vaccines as possible for each country. However, due to heavy global demand, there are strains in global vaccine production. The use of a plant biotechnology-based expression system for vaccine production also represents one part of this international effort, which is to develop plant-based heterologous expression systems, virus-like particles (VLPs)-vaccines, antiviral drugs, and a rapid supply of an-tigen-antibodies for detecting kits and plant origin bioactive compounds that boost the immunity and provide tolerance to fight against the virus infection. This review will look at the plant biotechnology platform that can provide the best fight against this global pandemic.
AB - Many pathogenic viral pandemics have caused threats to global health; the COVID-19 pandemic is the latest. Its transmission is growing exponentially all around the globe, putting constraints on the health system worldwide. A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes this pandemic. Many candidate vaccines are available at this time for COVID-19, and there is a massive international race underway to procure as many vaccines as possible for each country. However, due to heavy global demand, there are strains in global vaccine production. The use of a plant biotechnology-based expression system for vaccine production also represents one part of this international effort, which is to develop plant-based heterologous expression systems, virus-like particles (VLPs)-vaccines, antiviral drugs, and a rapid supply of an-tigen-antibodies for detecting kits and plant origin bioactive compounds that boost the immunity and provide tolerance to fight against the virus infection. This review will look at the plant biotechnology platform that can provide the best fight against this global pandemic.
KW - Bio-farming
KW - COVID-19 vaccine
KW - Respiratory disorder
KW - SARS-CoV-2 virus
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85107884131&partnerID=8YFLogxK
U2 - 10.3390/plants10061213
DO - 10.3390/plants10061213
M3 - Review article
AN - SCOPUS:85107884131
SN - 2223-7747
VL - 10
JO - Plants
JF - Plants
IS - 6
M1 - 1213
ER -