A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

Young Kwan Kim; Li Sheng Wang; Ryan Landis; Chang Soo Kim; Richard W. Vachet; Vincent M. Rotello

doi:10.1039/c7nr02949g

A layer-by-layer assembled MoS₂ thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

Young Kwan Kim, Li Sheng Wang, Ryan Landis, Chang Soo Kim, Richard W. Vachet, Vincent M. Rotello

Department of Chemistry

University of Massachusetts

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS₂ nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS₂ films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS₂ nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

Original language	English
Pages (from-to)	10854-10860
Number of pages	7
Journal	Nanoscale
Volume	9
Issue number	30
DOIs	https://doi.org/10.1039/c7nr02949g
State	Published - 14 Aug 2017

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title = "A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules",

abstract = "A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.",

author = "Kim, {Young Kwan} and Wang, {Li Sheng} and Ryan Landis and Kim, {Chang Soo} and Vachet, {Richard W.} and Rotello, {Vincent M.}",

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AU - Kim, Young Kwan

AU - Wang, Li Sheng

AU - Landis, Ryan

AU - Kim, Chang Soo

AU - Vachet, Richard W.

AU - Rotello, Vincent M.

PY - 2017/8/14

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N2 - A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

AB - A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

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JO - Nanoscale

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ER -

A layer-by-layer assembled MoS₂ thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

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