A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

Young Kwan Kim; Li Sheng Wang; Ryan Landis; Chang Soo Kim; Richard W. Vachet; Vincent M. Rotello

doi:10.1039/c7nr02949g

A layer-by-layer assembled MoS₂ thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

Young Kwan Kim
, Li Sheng Wang
, Ryan Landis
, Chang Soo Kim
, Richard W. Vachet
, Vincent M. Rotello

Department of Chemistry

University of Massachusetts

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS₂ nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS₂ films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS₂ nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

Original language	English
Pages (from-to)	10854-10860
Number of pages	7
Journal	Nanoscale
Volume	9
Issue number	30
DOIs	https://doi.org/10.1039/c7nr02949g
State	Published - 14 Aug 2017

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title = "A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules",

abstract = "A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.",

author = "Kim, \{Young Kwan\} and Wang, \{Li Sheng\} and Ryan Landis and Kim, \{Chang Soo\} and Vachet, \{Richard W.\} and Rotello, \{Vincent M.\}",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

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doi = "10.1039/c7nr02949g",

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AU - Kim, Young Kwan

AU - Wang, Li Sheng

AU - Landis, Ryan

AU - Kim, Chang Soo

AU - Vachet, Richard W.

AU - Rotello, Vincent M.

PY - 2017/8/14

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N2 - A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

AB - A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

UR - https://www.scopus.com/pages/publications/85027004579

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JO - Nanoscale

JF - Nanoscale

IS - 30

ER -

A layer-by-layer assembled MoS₂ thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules

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