A microfluidic blood-brain barrier platform comprised of intact and perfusable capillaries and astrocytes

Seokyoung Bang, Seung Ryeol Lee, Jihoon Ko, Kyungmin Son, Dongha Tahk, Jungho Ahn, Changkyun Im, Noo Li Jeon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A novel three dimensional blood-brain barrier (BBB) platform was developed by independently supplying different types of media to separate cell types within a device. One channel is connected to the inner lumen of the vascular network while the other supplies media to the neural cells. Compared to co-cultures supplied with only one type of medium, best barrier properties and viability were obtained with culturing huvecs with endothelial growth medium and neural cells with neurobasal medium supplemented with FBS independently. The measured vascular network permeability was comparable to reported in vivo values and a higher degree of neurovascular interfacing.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages149-150
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 22 Oct 201726 Oct 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Country/TerritoryUnited States
CitySavannah
Period22/10/1726/10/17

Keywords

  • Blood-Brain Barrier
  • Brain-On-A-Chip
  • Neurovascular Unit

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