A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor

Kyeong Lee, Hwan Mook Kim

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor produced by tumor cells under hypoxic conditions, and a key regulator of a number of genes important in cancer biology. Over-expression of HIF-1α in human tumors is associated with poor prognosis and poor therapeutic outcomes and HIF-1α has been suggested as a novel target for cancer therapy. This article provides a review of PX-478 as the first novel HIF-1α inhibitor in clinical stage for the treatment of solid tumors.

Original languageEnglish
Pages (from-to)1583-1585
Number of pages3
JournalArchives of Pharmacal Research
Volume34
Issue number10
DOIs
StatePublished - Oct 2011

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