A Novel Ferrocene-Linked Thionine as a Dual Redox Mediator for the Electrochemical Detection of Dopamine and Hydrogen Peroxide

Manikandan Palinci Nagarajan, Manikandan Ramalingam, Ilakeya Subbiah Arivuthilagam, Vishwa Paramaguru, Md Mahbubur Rahman, Jongdeok Park, Francis Kwaku Asiam, Byungjik Lee, Kwang Pyo Kim, Jae Joon Lee

Research output: Contribution to journalArticlepeer-review

Abstract

We introduce a novel dual redox mediator synthesized by covalently linking ferrocene dicarboxylic acid (FcDA) and thionine (TH) onto a pre-treated glassy carbon electrode. This unique structure significantly enhances the electro-oxidation of dopamine (DA) and the reduction of hydrogen peroxide (H2O2), offering a sensitive detection method for both analytes. The electrode exhibits exceptional sensitivity, selectivity, and stability, demonstrating potential for practical applications in biosensing. It facilitates rapid electron transfer between the analyte and the electrode surface, detecting H2O2 concentrations ranging from 1.5 to 60 µM with a limit of detection (LoD) of 0.49 µM and DA concentrations from 0.3 to 230 µM with an LoD of 0.07 µM. The electrode’s performance was validated through real-sample analyses, yielding satisfactory results.

Original languageEnglish
Article number448
JournalBiosensors
Volume14
Issue number9
DOIs
StatePublished - Sep 2024

Keywords

  • electro-oxidation
  • ferrocene
  • limit of detection
  • redox mediator
  • thionine

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