A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

Jungwoon Lee; Yan Xia; Mi Young Son; Guanghai Jin; Binna Seol; Min Jeong Kim; Myung Jin Son; Misol Do; Minho Lee; Dongsup Kim; Kyeong Lee; Yee Sook Cho

doi:10.1002/anie.201206691

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

Jungwoon Lee, Yan Xia, Mi Young Son, Guanghai Jin, Binna Seol, Min Jeong Kim, Myung Jin Son, Misol Do, Minho Lee, Dongsup Kim, Kyeong Lee, Yee Sook Cho

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

Original language	English
Pages (from-to)	12509-12513
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	50
DOIs	https://doi.org/10.1002/anie.201206691
State	Published - 7 Dec 2012

Keywords

gene expression
pluripotency
reprogramming
small molecules
stem cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201206691

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Lee, J., Xia, Y., Son, M. Y., Jin, G., Seol, B., Kim, M. J., Son, M. J., Do, M., Lee, M., Kim, D., Lee, K., & Cho, Y. S. (2012). A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. Angewandte Chemie - International Edition, 51(50), 12509-12513. https://doi.org/10.1002/anie.201206691

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abstract = "Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).",

keywords = "gene expression, pluripotency, reprogramming, small molecules, stem cells",

author = "Jungwoon Lee and Yan Xia and Son, {Mi Young} and Guanghai Jin and Binna Seol and Kim, {Min Jeong} and Son, {Myung Jin} and Misol Do and Minho Lee and Dongsup Kim and Kyeong Lee and Cho, {Yee Sook}",

year = "2012",

month = dec,

day = "7",

doi = "10.1002/anie.201206691",

language = "English",

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Lee, J, Xia, Y, Son, MY, Jin, G, Seol, B, Kim, MJ, Son, MJ, Do, M, Lee, M, Kim, D, Lee, K & Cho, YS 2012, 'A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells', Angewandte Chemie - International Edition, vol. 51, no. 50, pp. 12509-12513. https://doi.org/10.1002/anie.201206691

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. / Lee, Jungwoon; Xia, Yan; Son, Mi Young et al.
In: Angewandte Chemie - International Edition, Vol. 51, No. 50, 07.12.2012, p. 12509-12513.

Research output: Contribution to journal › Article › peer-review

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T1 - A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

AU - Lee, Jungwoon

AU - Xia, Yan

AU - Son, Mi Young

AU - Jin, Guanghai

AU - Seol, Binna

AU - Kim, Min Jeong

AU - Son, Myung Jin

AU - Do, Misol

AU - Lee, Minho

AU - Kim, Dongsup

AU - Lee, Kyeong

AU - Cho, Yee Sook

PY - 2012/12/7

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KW - reprogramming

KW - small molecules

KW - stem cells

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JO - Angewandte Chemie - International Edition

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IS - 50

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A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

Abstract

Keywords

UN SDGs

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