A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

Jungwoon Lee; Yan Xia; Mi Young Son; Guanghai Jin; Binna Seol; Min Jeong Kim; Myung Jin Son; Misol Do; Minho Lee; Dongsup Kim; Kyeong Lee; Yee Sook Cho

doi:10.1002/anie.201206691

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

Jungwoon Lee
, Yan Xia
, Mi Young Son
, Guanghai Jin
, Binna Seol
, Min Jeong Kim
, Myung Jin Son
, Misol Do
, Minho Lee
, Dongsup Kim
, Kyeong Lee
, Yee Sook Cho

Korea Research Institute of Bioscience and Biotechnology
Dongguk University
University of Science and Technology UST
Korea Advanced Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

Original language	English
Pages (from-to)	12509-12513
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	50
DOIs	https://doi.org/10.1002/anie.201206691
State	Published - 7 Dec 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

gene expression
pluripotency
reprogramming
small molecules
stem cells

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10.1002/anie.201206691

Cite this

Lee, J., Xia, Y., Son, M. Y., Jin, G., Seol, B., Kim, M. J., Son, M. J., Do, M., Lee, M., Kim, D., Lee, K., & Cho, Y. S. (2012). A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. Angewandte Chemie - International Edition, 51(50), 12509-12513. https://doi.org/10.1002/anie.201206691

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abstract = "Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).",

keywords = "gene expression, pluripotency, reprogramming, small molecules, stem cells",

author = "Jungwoon Lee and Yan Xia and Son, \{Mi Young\} and Guanghai Jin and Binna Seol and Kim, \{Min Jeong\} and Son, \{Myung Jin\} and Misol Do and Minho Lee and Dongsup Kim and Kyeong Lee and Cho, \{Yee Sook\}",

year = "2012",

month = dec,

day = "7",

doi = "10.1002/anie.201206691",

language = "English",

volume = "51",

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}

Lee, J, Xia, Y, Son, MY, Jin, G, Seol, B, Kim, MJ, Son, MJ, Do, M, Lee, M, Kim, D, Lee, K & Cho, YS 2012, 'A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells', Angewandte Chemie - International Edition, vol. 51, no. 50, pp. 12509-12513. https://doi.org/10.1002/anie.201206691

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. / Lee, Jungwoon; Xia, Yan; Son, Mi Young et al.
In: Angewandte Chemie - International Edition, Vol. 51, No. 50, 07.12.2012, p. 12509-12513.

Research output: Contribution to journal › Article › peer-review

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T1 - A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

AU - Lee, Jungwoon

AU - Xia, Yan

AU - Son, Mi Young

AU - Jin, Guanghai

AU - Seol, Binna

AU - Kim, Min Jeong

AU - Son, Myung Jin

AU - Do, Misol

AU - Lee, Minho

AU - Kim, Dongsup

AU - Lee, Kyeong

AU - Cho, Yee Sook

PY - 2012/12/7

Y1 - 2012/12/7

N2 - Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

AB - Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

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KW - pluripotency

KW - reprogramming

KW - small molecules

KW - stem cells

UR - https://www.scopus.com/pages/publications/84870586551

U2 - 10.1002/anie.201206691

DO - 10.1002/anie.201206691

M3 - Article

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 50

ER -

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

Abstract

UN SDGs

Keywords

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