A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata

Tien Dat Nguyen; Kyeong Lee; Young Soo Hong; Ho Kim Young; Van Minh Chau; Joon Lee Jung

doi:10.1055/s-0029-1185386

A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata

Tien Dat Nguyen, Kyeong Lee, Young Soo Hong, Ho Kim Young, Van Minh Chau, Joon Lee Jung

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid and glucose metabolism and have become important therapeutic targets for various diseases. The phytochemical investigation of the chloroform-soluble extract of Chromolaena odorata led to the isolation of a PPAR-γ agonist, (9S,13R)-12-oxo-phytodienoic acid (1), together with 12 other compounds. The structures of chromomoric acid G (2), a new dehydrogenated derivative of 1, and chromolanone (3) were elucidated based on spectroscopic methods. Compound 1 showed a significant effect on PPAR-γ activation in comparison with rosiglitazone. However, compound 2 was inactive, suggesting that the dehydrogenation of the prostaglandin-like structure in 1 abrogates its PPAR-γ agonistic activity.

Original language	English
Pages (from-to)	803-807
Number of pages	5
Journal	Planta Medica
Volume	75
Issue number	8
DOIs	https://doi.org/10.1055/s-0029-1185386
State	Published - Jun 2009

Keywords

(9S,13R)-12-oxo-phytodienoic acid
Asteraceae
Chromolaena odorata
Chromomoric acid G
PPAR-γ

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10.1055/s-0029-1185386

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title = "A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata",

abstract = "Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid and glucose metabolism and have become important therapeutic targets for various diseases. The phytochemical investigation of the chloroform-soluble extract of Chromolaena odorata led to the isolation of a PPAR-γ agonist, (9S,13R)-12-oxo-phytodienoic acid (1), together with 12 other compounds. The structures of chromomoric acid G (2), a new dehydrogenated derivative of 1, and chromolanone (3) were elucidated based on spectroscopic methods. Compound 1 showed a significant effect on PPAR-γ activation in comparison with rosiglitazone. However, compound 2 was inactive, suggesting that the dehydrogenation of the prostaglandin-like structure in 1 abrogates its PPAR-γ agonistic activity.",

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T1 - A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata

AU - Nguyen, Tien Dat

AU - Lee, Kyeong

AU - Hong, Young Soo

AU - Young, Ho Kim

AU - Chau, Van Minh

AU - Jung, Joon Lee

PY - 2009/6

Y1 - 2009/6

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AB - Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid and glucose metabolism and have become important therapeutic targets for various diseases. The phytochemical investigation of the chloroform-soluble extract of Chromolaena odorata led to the isolation of a PPAR-γ agonist, (9S,13R)-12-oxo-phytodienoic acid (1), together with 12 other compounds. The structures of chromomoric acid G (2), a new dehydrogenated derivative of 1, and chromolanone (3) were elucidated based on spectroscopic methods. Compound 1 showed a significant effect on PPAR-γ activation in comparison with rosiglitazone. However, compound 2 was inactive, suggesting that the dehydrogenation of the prostaglandin-like structure in 1 abrogates its PPAR-γ agonistic activity.

KW - (9S,13R)-12-oxo-phytodienoic acid

KW - Asteraceae

KW - Chromolaena odorata

KW - Chromomoric acid G

KW - PPAR-γ

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A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata

Abstract

Keywords

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