Abstract
A practical synthesis of 2'-deoxy-2'-fluoro-5-methyl-β-L- arabinofuranosyl uracil (14, L-FMAU) was developed from L-arabinose. L- Arabinose was convened to L-ribose 5, which was used for the synthesis of bromosugar 12 via 2,3,5-O-tribenzoyl-1-O-acetyl-β-L-ribofuranose 8, which was subjected to condensation with silylated thymine and the resulting protected L-FMAU 13 was deprotected to afford L-FMAU in 14 steps in 8% overall yield.
Original language | English |
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Pages (from-to) | 187-195 |
Number of pages | 9 |
Journal | Nucleosides and Nucleotides |
Volume | 18 |
Issue number | 2 |
DOIs | |
State | Published - 1999 |