TY - JOUR
T1 - Accelerated lung aging and chronic obstructive pulmonary disease
AU - Yoon, Young Soon
AU - Jin, Minhee
AU - Sin, Don D.
N1 - Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/4/3
Y1 - 2019/4/3
N2 - Introduction: The prevalence of chronic obstructive pulmonary disease (COPD) increases exponentially with aging. Its pathogenesis, however, is not well known and aside from smoking cessation, there are no disease-modifying treatments for this disease. Areas covered: COPD is associated with accelerating aging and aging-related diseases. In this review, we will discuss the hallmarks of aging including genomic instability, telomere attrition, epigenetic alteration, loss of proteostasis, mitochondrial dysfunction, deregulated nutrient sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication, which may be involved in COPD pathogenesis. Expert commentary: COPD and the aging process share similar molecular and cellular changes. Aging-related molecular pathways may represent novel therapeutic targets and biomarkers for COPD.
AB - Introduction: The prevalence of chronic obstructive pulmonary disease (COPD) increases exponentially with aging. Its pathogenesis, however, is not well known and aside from smoking cessation, there are no disease-modifying treatments for this disease. Areas covered: COPD is associated with accelerating aging and aging-related diseases. In this review, we will discuss the hallmarks of aging including genomic instability, telomere attrition, epigenetic alteration, loss of proteostasis, mitochondrial dysfunction, deregulated nutrient sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication, which may be involved in COPD pathogenesis. Expert commentary: COPD and the aging process share similar molecular and cellular changes. Aging-related molecular pathways may represent novel therapeutic targets and biomarkers for COPD.
KW - aging
KW - Chronic obstructive pulmonary disease
KW - senescence
UR - http://www.scopus.com/inward/record.url?scp=85063200179&partnerID=8YFLogxK
U2 - 10.1080/17476348.2019.1580576
DO - 10.1080/17476348.2019.1580576
M3 - Review article
C2 - 30735057
AN - SCOPUS:85063200179
SN - 1747-6348
VL - 13
SP - 369
EP - 380
JO - Expert Review of Respiratory Medicine
JF - Expert Review of Respiratory Medicine
IS - 4
ER -