Accelerated lung aging and chronic obstructive pulmonary disease

Young Soon Yoon, Minhee Jin, Don D. Sin

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Introduction: The prevalence of chronic obstructive pulmonary disease (COPD) increases exponentially with aging. Its pathogenesis, however, is not well known and aside from smoking cessation, there are no disease-modifying treatments for this disease. Areas covered: COPD is associated with accelerating aging and aging-related diseases. In this review, we will discuss the hallmarks of aging including genomic instability, telomere attrition, epigenetic alteration, loss of proteostasis, mitochondrial dysfunction, deregulated nutrient sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication, which may be involved in COPD pathogenesis. Expert commentary: COPD and the aging process share similar molecular and cellular changes. Aging-related molecular pathways may represent novel therapeutic targets and biomarkers for COPD.

Original languageEnglish
Pages (from-to)369-380
Number of pages12
JournalExpert Review of Respiratory Medicine
Volume13
Issue number4
DOIs
StatePublished - 3 Apr 2019

Keywords

  • aging
  • Chronic obstructive pulmonary disease
  • senescence

Fingerprint

Dive into the research topics of 'Accelerated lung aging and chronic obstructive pulmonary disease'. Together they form a unique fingerprint.

Cite this