TY - JOUR
T1 - Acinetobacter baumannii
T2 - An overview of emerging multidrug-resistant pathogen
AU - Gautam, Deepan
AU - Dolma, Karma G.
AU - Khandelwal, Bidita
AU - Mitsuwan, Watcharapong
AU - Mahboob, Tooba
AU - Pereira, Maria de Lourdes
AU - Nawaz, Muhammad
AU - Wiart, Christophe
AU - Ardebili, Abdollah
AU - Siyadatpanah, Abolghasem
AU - Ehtesham, Hamideh
AU - Patra, Jayanta Kumar
AU - Kwanhian, Wiyada
AU - Nissapatorn, Veeranoot
N1 - Publisher Copyright:
© 2022, Malaysian Medical Association. All rights reserved.
PY - 2022/5
Y1 - 2022/5
N2 - The emergence of infections caused by Acinetobacter baumannii, a multidrug-resistant bacterium, has been a concern worldwide. This bacterium is an important hospitalacquired pathogen that causes several diseases including ventilator-associated pneumonia, bloodstream infections, and meningitis. This study aimed to determine antibioticresistant mechanisms in the pathogenesis of A. baumannii and the alternative treatment strategies against it. The combined actions of outer membrane protein A, formation of a biofilm on biotic and abiotic surfaces, phospholipases C and D, metal homeostatic system, lipopolysaccharides, and verotoxins are relevant for virulence and pathogenesis. A. baumannii resists the broad-spectrum antibiotics by its mechanisms of resistance, such as β-lactamases, efflux pump, aminoglycoside modifying enzymes, permeability changes, and alternation of targets. In an attempt to overcome the resistance mechanisms, plant-derived compounds and a combination of the antibiotics and the plant phytocompounds have been focused. Nanoparticles synthesised with the plant extract have been studied extensively. Furthermore, we projected modern methods, including multi-omics analysis, to study insight into mechanisms of actions of antibiotics. The information suggested that the potential antibiotic mechanisms of A. baumannii could lead to an alternative treatment against A. baumannii infections.
AB - The emergence of infections caused by Acinetobacter baumannii, a multidrug-resistant bacterium, has been a concern worldwide. This bacterium is an important hospitalacquired pathogen that causes several diseases including ventilator-associated pneumonia, bloodstream infections, and meningitis. This study aimed to determine antibioticresistant mechanisms in the pathogenesis of A. baumannii and the alternative treatment strategies against it. The combined actions of outer membrane protein A, formation of a biofilm on biotic and abiotic surfaces, phospholipases C and D, metal homeostatic system, lipopolysaccharides, and verotoxins are relevant for virulence and pathogenesis. A. baumannii resists the broad-spectrum antibiotics by its mechanisms of resistance, such as β-lactamases, efflux pump, aminoglycoside modifying enzymes, permeability changes, and alternation of targets. In an attempt to overcome the resistance mechanisms, plant-derived compounds and a combination of the antibiotics and the plant phytocompounds have been focused. Nanoparticles synthesised with the plant extract have been studied extensively. Furthermore, we projected modern methods, including multi-omics analysis, to study insight into mechanisms of actions of antibiotics. The information suggested that the potential antibiotic mechanisms of A. baumannii could lead to an alternative treatment against A. baumannii infections.
KW - Acinetobacter baumannii
KW - Advance diagnostic
KW - And Plant-derived compounds
KW - Hospital-acquired infection
KW - Multidrug resistance
KW - Nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85131166249&partnerID=8YFLogxK
M3 - Review article
C2 - 35638493
AN - SCOPUS:85131166249
SN - 0300-5283
VL - 77
SP - 357
EP - 370
JO - Medical Journal of Malaysia
JF - Medical Journal of Malaysia
IS - 3
ER -