Activation of the phosphatidylinositol 3-kinase/Akt pathway by viral interferon regulatory factor 2 of Kaposi's sarcoma-associated herpesvirus

Yejin Kim, Seho Cha, Taegun Seo

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Kaposi's sarcoma-associated herpesvirus encodes several genes with sequence homology to cellular interferon regulatory factors. Among these, vIRF2 encoded by ORF K11.1 (short form) or K11 (full-length) participates in caspase-3-mediated inactivation of cellular IRF3 and slightly inhibits caspase-3 activity. Here, we have demonstrated that vIRF2 attenuates the transcriptional activity of forkhead box O3A protein via activation of the PI3K/Akt phosphatidylinositol 3-kinase/Akt pathway, inhibiting FOXO3A-mediated caspase-3 cleavage. Based on the collective findings, we suggest that vIRF2 acts as an activator in PI3K/Akt pathway.

Original languageEnglish
Pages (from-to)650-656
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume470
Issue number3
DOIs
StatePublished - 12 Feb 2016

Keywords

  • Caspase-3
  • FOXO3A
  • KSHV
  • PI3K/Akt pathway
  • vIRF2

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