Abstract
Kaposi's sarcoma-associated herpesvirus encodes several genes with sequence homology to cellular interferon regulatory factors. Among these, vIRF2 encoded by ORF K11.1 (short form) or K11 (full-length) participates in caspase-3-mediated inactivation of cellular IRF3 and slightly inhibits caspase-3 activity. Here, we have demonstrated that vIRF2 attenuates the transcriptional activity of forkhead box O3A protein via activation of the PI3K/Akt phosphatidylinositol 3-kinase/Akt pathway, inhibiting FOXO3A-mediated caspase-3 cleavage. Based on the collective findings, we suggest that vIRF2 acts as an activator in PI3K/Akt pathway.
Original language | English |
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Pages (from-to) | 650-656 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 470 |
Issue number | 3 |
DOIs | |
State | Published - 12 Feb 2016 |
Keywords
- Caspase-3
- FOXO3A
- KSHV
- PI3K/Akt pathway
- vIRF2