Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa

Hyun Woo Kim; Junha Park; Kyo Bin Kang; Tae Bum Kim; Won Keun Oh; Jinwoong Kim; Sang Hyun Sung

doi:10.1021/acs.jnatprod.6b00566

Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa

Hyun Woo Kim, Junha Park, Kyo Bin Kang, Tae Bum Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung

Department of Pharmacy

Seoul National University

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Eight new compounds (1-8), including five acylphloroglucinolated catechins (1-5) and three phenylethyl isocoumarin glycosides (6-8), were isolated from Agrimonia pilosa along with six other known compounds (9-14). The new compounds were characterized structurally by NMR, MS, and ECD analyses. Compounds 4 and 5 were assigned as acylphloroglucinolated procyanidin derivatives, which are described for the first time from Nature. The absolute configuration of compound 8 was elucidated by computational analysis of its ECD spectrum. The isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced NO production in BV2 microglial cells.

Original language	English
Pages (from-to)	2376-2383
Number of pages	8
Journal	Journal of Natural Products
Volume	79
Issue number	9
DOIs	https://doi.org/10.1021/acs.jnatprod.6b00566
State	Published - 23 Sep 2016

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abstract = "Eight new compounds (1-8), including five acylphloroglucinolated catechins (1-5) and three phenylethyl isocoumarin glycosides (6-8), were isolated from Agrimonia pilosa along with six other known compounds (9-14). The new compounds were characterized structurally by NMR, MS, and ECD analyses. Compounds 4 and 5 were assigned as acylphloroglucinolated procyanidin derivatives, which are described for the first time from Nature. The absolute configuration of compound 8 was elucidated by computational analysis of its ECD spectrum. The isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced NO production in BV2 microglial cells.",

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AU - Oh, Won Keun

AU - Kim, Jinwoong

AU - Sung, Sang Hyun

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Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa

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