TY - JOUR
T1 - Adult male-specific inverse association between dry eye disease and intraocular pressure
T2 - KNHANES 2010-2012
AU - Choi, Yun Hee
AU - Kim, Martha
AU - Choi, Yoon Hyeong
AU - Kim, Dong Hyun
N1 - Publisher Copyright:
© 2025 Choi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2025/2
Y1 - 2025/2
N2 - Purpose To investigate the association between dry eye disease (DED) and intraocular pressure (IOP) in the general adult population of South Korea. Methods We enrolled 13,194 adults (age ≥19 years) who had participated in the fifth Korea National Health and Nutrition Examination Survey conducted from 2010 to 2012. IOP was measured using Goldman applanation tonometry. DED was defined as the presence of self-reported symptoms along with a diagnosis by an ophthalmologist. As the correlation between the left and right eyes was high (r = 0.833), only the measurement values of the right eye were used. We sequentially conducted multiple linear and logistic regression analyses to investigate the association between DED and IOP and prevalence of high IOP (>21 mmHg). Results The prevalence of DED in Korean adults was 7.8%, and the geometric mean of IOP in the right eye was 13.7 ± 1.0 mmHg. In the fully adjusted model, participants with DED had a significantly lower IOP compared to those without DED in the overall population (β = -0.032; 95% confidence interval [CI]: -0.059, -0.004). This trend was evident in males (β = -0.059; 95% CI: -0.106, -0.012) but not in females. Similarly, males with DED had a significantly lower prevalence of high IOP compared to those without DED (odds ratio [OR] = 0.18; 95% CI: 0.04, 0.91), but this association was not evident in females. Conclusions This study suggests that DED is associated with lower IOP in adult Korean males.
AB - Purpose To investigate the association between dry eye disease (DED) and intraocular pressure (IOP) in the general adult population of South Korea. Methods We enrolled 13,194 adults (age ≥19 years) who had participated in the fifth Korea National Health and Nutrition Examination Survey conducted from 2010 to 2012. IOP was measured using Goldman applanation tonometry. DED was defined as the presence of self-reported symptoms along with a diagnosis by an ophthalmologist. As the correlation between the left and right eyes was high (r = 0.833), only the measurement values of the right eye were used. We sequentially conducted multiple linear and logistic regression analyses to investigate the association between DED and IOP and prevalence of high IOP (>21 mmHg). Results The prevalence of DED in Korean adults was 7.8%, and the geometric mean of IOP in the right eye was 13.7 ± 1.0 mmHg. In the fully adjusted model, participants with DED had a significantly lower IOP compared to those without DED in the overall population (β = -0.032; 95% confidence interval [CI]: -0.059, -0.004). This trend was evident in males (β = -0.059; 95% CI: -0.106, -0.012) but not in females. Similarly, males with DED had a significantly lower prevalence of high IOP compared to those without DED (odds ratio [OR] = 0.18; 95% CI: 0.04, 0.91), but this association was not evident in females. Conclusions This study suggests that DED is associated with lower IOP in adult Korean males.
UR - http://www.scopus.com/inward/record.url?scp=85218088983&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0315010
DO - 10.1371/journal.pone.0315010
M3 - Article
C2 - 39951397
AN - SCOPUS:85218088983
SN - 1932-6203
VL - 20
JO - PLoS ONE
JF - PLoS ONE
IS - 2 February
M1 - e0315010
ER -