Advances in electrochemical aptasensing for cardiac biomarkers

Md Mahbubur Rahman, Nasrin Siraj Lopa, Jae Joon Lee

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Novel bio-receptors or bio-recognition molecular markers with high specificity, stability, and affinity for the efficient binding and entrapment of target biomolecules are essential for developing biomedical devices with high sensitivity and reliability. Aptamers are peptide or nucleic-acid (DNA or RNA) molecules capable of binding to target biomarkers by forming a unique three-dimensional structure, providing an effective platform for biosensing. This review comprehensively summarizes the progress of label-free and label-based electrochemical aptasensors for the detection of various biomarkers related to cardiovascular diseases. It also outlines the fundamental properties of different cardiac biomarkers, synthesis of target-specific aptamers, and working principles, such as single receptor and sandwich, of the different types of sensing assays for the electrochemical detection of cardiac biomarkers while highlighting the current challenges and future perspectives.

Original languageEnglish
Pages (from-to)51-68
Number of pages18
JournalBulletin of the Korean Chemical Society
Volume43
Issue number1
DOIs
StatePublished - Jan 2022

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