Age-related changes in microvillar cells of rat olfactory epithelium

Bum Sun Kwon; Min Kyu Kim; Woo Ho Kim; Jung Soo Pyo; Young Hee Cheon; Choong Ik Cha; Seon Young Nam; Tai Kyoung Baik; Byung Lan Lee

doi:10.1016/j.neulet.2004.11.094

Age-related changes in microvillar cells of rat olfactory epithelium

Bum Sun Kwon, Min Kyu Kim, Woo Ho Kim, Jung Soo Pyo, Young Hee Cheon, Choong Ik Cha, Seon Young Nam, Tai Kyoung Baik, Byung Lan Lee

Department of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The nature and function of microvillar cells (MVCs) of the mammalian olfactory epithelium (OE) are little understood. Previous studies have examined MVC morphology in the developing and mature OE, but not in the aged OE. The present study investigated the effect of aging on MVCs of the OE in male Sprague-Dawley rats using histological and immunohistochemical methods. OE of aged rats contained MVCs with marked hypertrophy and swollen end-feet, which reached the basement membrane. Such MVC features were not observed in the young OE. These MVC changes were more conspicuous in proximity to severely degenerated olfactory receptor neurons (ORNs) and supporting cells. The ratio of the number of MVCs to that of supporting cells increased with aging; however, MVCs in the aged OE were not proliferating cell nuclear antigen-immunoreactive. In addition, the total cell population was decreased in the aged OE. Thus, our results suggest that MVCs are non-neuronal and that they are more resistant to aging compared to ORNs and supporting cells.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	Neuroscience Letters
Volume	378
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2004.11.094
State	Published - 18 Apr 2005

Keywords

Aged rat
Hypertrophy
Microvillar cell
Olfactory epithelium

Access to Document

10.1016/j.neulet.2004.11.094

Cite this

@article{32a4587de52648049497edf714383e0c,

title = "Age-related changes in microvillar cells of rat olfactory epithelium",

abstract = "The nature and function of microvillar cells (MVCs) of the mammalian olfactory epithelium (OE) are little understood. Previous studies have examined MVC morphology in the developing and mature OE, but not in the aged OE. The present study investigated the effect of aging on MVCs of the OE in male Sprague-Dawley rats using histological and immunohistochemical methods. OE of aged rats contained MVCs with marked hypertrophy and swollen end-feet, which reached the basement membrane. Such MVC features were not observed in the young OE. These MVC changes were more conspicuous in proximity to severely degenerated olfactory receptor neurons (ORNs) and supporting cells. The ratio of the number of MVCs to that of supporting cells increased with aging; however, MVCs in the aged OE were not proliferating cell nuclear antigen-immunoreactive. In addition, the total cell population was decreased in the aged OE. Thus, our results suggest that MVCs are non-neuronal and that they are more resistant to aging compared to ORNs and supporting cells.",

keywords = "Aged rat, Hypertrophy, Microvillar cell, Olfactory epithelium",

author = "Kwon, {Bum Sun} and Kim, {Min Kyu} and Kim, {Woo Ho} and Pyo, {Jung Soo} and Cheon, {Young Hee} and Cha, {Choong Ik} and Nam, {Seon Young} and Baik, {Tai Kyoung} and Lee, {Byung Lan}",

year = "2005",

month = apr,

day = "18",

doi = "10.1016/j.neulet.2004.11.094",

language = "English",

volume = "378",

pages = "65--69",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Age-related changes in microvillar cells of rat olfactory epithelium

AU - Kwon, Bum Sun

AU - Kim, Min Kyu

AU - Kim, Woo Ho

AU - Pyo, Jung Soo

AU - Cheon, Young Hee

AU - Cha, Choong Ik

AU - Nam, Seon Young

AU - Baik, Tai Kyoung

AU - Lee, Byung Lan

PY - 2005/4/18

Y1 - 2005/4/18

N2 - The nature and function of microvillar cells (MVCs) of the mammalian olfactory epithelium (OE) are little understood. Previous studies have examined MVC morphology in the developing and mature OE, but not in the aged OE. The present study investigated the effect of aging on MVCs of the OE in male Sprague-Dawley rats using histological and immunohistochemical methods. OE of aged rats contained MVCs with marked hypertrophy and swollen end-feet, which reached the basement membrane. Such MVC features were not observed in the young OE. These MVC changes were more conspicuous in proximity to severely degenerated olfactory receptor neurons (ORNs) and supporting cells. The ratio of the number of MVCs to that of supporting cells increased with aging; however, MVCs in the aged OE were not proliferating cell nuclear antigen-immunoreactive. In addition, the total cell population was decreased in the aged OE. Thus, our results suggest that MVCs are non-neuronal and that they are more resistant to aging compared to ORNs and supporting cells.

AB - The nature and function of microvillar cells (MVCs) of the mammalian olfactory epithelium (OE) are little understood. Previous studies have examined MVC morphology in the developing and mature OE, but not in the aged OE. The present study investigated the effect of aging on MVCs of the OE in male Sprague-Dawley rats using histological and immunohistochemical methods. OE of aged rats contained MVCs with marked hypertrophy and swollen end-feet, which reached the basement membrane. Such MVC features were not observed in the young OE. These MVC changes were more conspicuous in proximity to severely degenerated olfactory receptor neurons (ORNs) and supporting cells. The ratio of the number of MVCs to that of supporting cells increased with aging; however, MVCs in the aged OE were not proliferating cell nuclear antigen-immunoreactive. In addition, the total cell population was decreased in the aged OE. Thus, our results suggest that MVCs are non-neuronal and that they are more resistant to aging compared to ORNs and supporting cells.

KW - Aged rat

KW - Hypertrophy

KW - Microvillar cell

KW - Olfactory epithelium

UR - http://www.scopus.com/inward/record.url?scp=14844360849&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2004.11.094

DO - 10.1016/j.neulet.2004.11.094

M3 - Article

C2 - 15774259

AN - SCOPUS:14844360849

SN - 0304-3940

VL - 378

SP - 65

EP - 69

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Age-related changes in microvillar cells of rat olfactory epithelium

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this