An asymmetric total synthesis of (-)-fumagillol

Deukjoon Kim, Soon Kil Ahn, Hoon Bae, Won Jun Choi, Hak Sung Kim

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

(-)-Fumagillol (2), a hydrolysis product of fumagillin (1), has been synthesized in a highly stereoselective manner utilizing a glycolate Claisen rearrangement and an intramolecular ester enolate alkylation as key steps starting from carbohydrate-based precursor 5.

Original languageEnglish
Pages (from-to)4437-4440
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number25
DOIs
StatePublished - 23 Jun 1997

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