An asymmetric total synthesis of (-)-fumagillol

Deukjoon Kim; Soon Kil Ahn; Hoon Bae; Won Jun Choi; Hak Sung Kim

doi:10.1016/S0040-4039(97)00925-8

An asymmetric total synthesis of (-)-fumagillol

Deukjoon Kim
, Soon Kil Ahn
, Hoon Bae
, Won Jun Choi
, Hak Sung Kim

Department of Pharmacy

Seoul National University

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

(-)-Fumagillol (2), a hydrolysis product of fumagillin (1), has been synthesized in a highly stereoselective manner utilizing a glycolate Claisen rearrangement and an intramolecular ester enolate alkylation as key steps starting from carbohydrate-based precursor 5.

Original language	English
Pages (from-to)	4437-4440
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	25
DOIs	https://doi.org/10.1016/S0040-4039(97)00925-8
State	Published - 23 Jun 1997

Access to Document

10.1016/S0040-4039(97)00925-8

Cite this

@article{dd1a1be4b8a947b48d94aaaf49f5c838,

title = "An asymmetric total synthesis of (-)-fumagillol",

abstract = "(-)-Fumagillol (2), a hydrolysis product of fumagillin (1), has been synthesized in a highly stereoselective manner utilizing a glycolate Claisen rearrangement and an intramolecular ester enolate alkylation as key steps starting from carbohydrate-based precursor 5.",

author = "Deukjoon Kim and Ahn, \{Soon Kil\} and Hoon Bae and Choi, \{Won Jun\} and Kim, \{Hak Sung\}",

year = "1997",

month = jun,

day = "23",

doi = "10.1016/S0040-4039(97)00925-8",

language = "English",

volume = "38",

pages = "4437--4440",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "25",

}

TY - JOUR

T1 - An asymmetric total synthesis of (-)-fumagillol

AU - Kim, Deukjoon

AU - Ahn, Soon Kil

AU - Bae, Hoon

AU - Choi, Won Jun

AU - Kim, Hak Sung

PY - 1997/6/23

Y1 - 1997/6/23

N2 - (-)-Fumagillol (2), a hydrolysis product of fumagillin (1), has been synthesized in a highly stereoselective manner utilizing a glycolate Claisen rearrangement and an intramolecular ester enolate alkylation as key steps starting from carbohydrate-based precursor 5.

AB - (-)-Fumagillol (2), a hydrolysis product of fumagillin (1), has been synthesized in a highly stereoselective manner utilizing a glycolate Claisen rearrangement and an intramolecular ester enolate alkylation as key steps starting from carbohydrate-based precursor 5.

UR - https://www.scopus.com/pages/publications/0030986585

U2 - 10.1016/S0040-4039(97)00925-8

DO - 10.1016/S0040-4039(97)00925-8

M3 - Article

AN - SCOPUS:0030986585

SN - 0040-4039

VL - 38

SP - 4437

EP - 4440

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 25

ER -

An asymmetric total synthesis of (-)-fumagillol

Abstract

Access to Document

Other files and links

Fingerprint

Cite this