Analysis of Folate by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Sangwon Cha, Hie Joon Kim

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to observe folic acid and its derivatives such as tetrahydrofolate and 5-methyltetrahydrofolate in a vitamin tablet and in foods. Folic acid in a vitamin tablet was determined using angiotensin I as an internal reference. Tetrahydrofolic acid, 5-methyltetrahydrofolic acid, and an oxygenated folate were observed from a human blood sample using graphite plate. The results show that these mass spectrometric methods are useful for quickly obtaining a profile of folates.

Original languageEnglish
Pages (from-to)1308-1312
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume24
Issue number9
DOIs
StatePublished - 20 Sep 2003

Keywords

  • Blood
  • Folate
  • Graphite plate
  • MALDI-TOF MS
  • Vitamin

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