Analytical insights of COVID-19 pandemic

Gayathri Chellasamy, Shiva Kumar Arumugasamy, Saravanan Govindaraju, Kyusik Yun

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (2019-nCoV or SARS-CoV-2). Genomic analysis has revealed that bat and pangolin coronaviruses are phylogenetically related to SARS-CoV-2. The actual origin and passage history of the virus are unknown, but human-human transmission of the virus has been confirmed. Several diagnostic techniques have been developed to detect COVID-19 in this prevailing pandemic period. In this review, we provide an overview of SARS-CoV-2 and other coronaviruses. The origin, structure, current diagnostic techniques, such as molecular assays based on oligonucleotides, immunoassay-based detection, nanomaterial-based biosensing, and distinctive sample based detection are also discussed. Furthermore, our review highlights the admissible treatment strategies for COVID-19 and future perspectives on the development of biosensing techniques and vaccines for the diagnosis and prevention of the disease, respectively.

Original languageEnglish
Article number116072
JournalTrAC - Trends in Analytical Chemistry
Volume133
DOIs
StatePublished - Dec 2020

Keywords

  • COVID-19
  • Diagnostic techniques
  • Genome
  • Pandemic outbreak
  • Treatment
  • Vaccines

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