Abstract
Background: In this study, indica rice (Oryza sativa L.) was bioconversioned using Lactobacillus plantarum ATCC14917 and Lactobacillus rhamnosus GG KCTC5033. Results: Compared to the control treatment (RE), rice extract fermented with Lactobacillus plantarum ATCC14917 (LP-RE) and Lactobacillus rhamnosus GG KCTC5033 (LR-RE) inhibited the growth of pathogenic bacteria significantly except for E. coli O157:H7 (p < 0.05). The LR-RE treatment had the strongest inhibitory effect on Staphylococcus aureus biofilm formation (10.81 ± 1.98%). Additionally, real-time PCR analyses confirmed that LP-RE inhibited S. aureus-induced IL-8 expression in Caco-2 cells by 60%. HPLC-orbitrap analysis indicated that this treatment increased the levels of key metabolites with therapeutic properties such as acetophenone, 9-oxo-10(E), 12(E)-octadecadienoic acid, nicotinic acid, and indol-3-lactic acid. Conclusions: This study demonstrated that the secondary metabolites were linked to antibacterial and anti-inflammatory effects, suggesting that bioconversion is a promising means to produce dietary supplements with therapeutic properties. Graphical Abstract: [Figure not available: see fulltext.]
Original language | English |
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Article number | 44 |
Journal | Chemical and Biological Technologies in Agriculture |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - Dec 2022 |
Keywords
- Anti-bacterial
- Anti-inflammatory
- Bioconversion
- Indica rice
- Lactic acid bacteria
- Secondary metabolite