Anti-inflammatory effects of 6,8-diprenyl-7,4′-dihydroxyflavanone from Sophora tonkinensis on lipopolysaccharide-stimulated RAW 264.7 cells

Hee Sung Chae; Hunseung Yoo; Young Mi Kim; Young Hee Choi; Chang Hoon Lee; Young Won Chin

doi:10.3390/molecules21081049

Anti-inflammatory effects of 6,8-diprenyl-7,4′-dihydroxyflavanone from Sophora tonkinensis on lipopolysaccharide-stimulated RAW 264.7 cells

Hee Sung Chae, Hunseung Yoo, Young Mi Kim, Young Hee Choi, Chang Hoon Lee, Young Won Chin

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The anti-inflammatory effects and molecular mechanism of 6,8-diprenyl-7,4′-dihydroxyflavanone (DDF), one of the flavanones found in Sophora tonkinensis, were assessed in vitro through macrophage-mediated inflammation in the present study. The anti-inflammatory effects of DDF were not previously reported. DDF inhibited the production of nitric oxide and the expression of tumor necrosis factor α, interleukin-1β, and interleukin-6. Furthermore, the activation of nuclear factor-κB (NF-κB) and extracellular signal-regulated kinases (ERKs) in lipopolysaccharide-stimulated macrophages was suppressed by treatment with DDF. Therefore, DDF demonstrated potentially anti-inflammatory effects via the blockade of NF-κB and ERK activation in macrophages.

Original language	English
Article number	1049
Journal	Molecules
Volume	21
Issue number	8
DOIs	https://doi.org/10.3390/molecules21081049
State	Published - 1 Aug 2016

Keywords

6,8-diprenyl-7,4′-dihydroxyflavanone;
Anti-inflammatory;
Extracellular signal-regulated kinases
Nuclear factor-κB;

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10.3390/molecules21081049

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title = "Anti-inflammatory effects of 6,8-diprenyl-7,4′-dihydroxyflavanone from Sophora tonkinensis on lipopolysaccharide-stimulated RAW 264.7 cells",

abstract = "The anti-inflammatory effects and molecular mechanism of 6,8-diprenyl-7,4′-dihydroxyflavanone (DDF), one of the flavanones found in Sophora tonkinensis, were assessed in vitro through macrophage-mediated inflammation in the present study. The anti-inflammatory effects of DDF were not previously reported. DDF inhibited the production of nitric oxide and the expression of tumor necrosis factor α, interleukin-1β, and interleukin-6. Furthermore, the activation of nuclear factor-κB (NF-κB) and extracellular signal-regulated kinases (ERKs) in lipopolysaccharide-stimulated macrophages was suppressed by treatment with DDF. Therefore, DDF demonstrated potentially anti-inflammatory effects via the blockade of NF-κB and ERK activation in macrophages.",

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author = "Chae, {Hee Sung} and Hunseung Yoo and Kim, {Young Mi} and Choi, {Young Hee} and Lee, {Chang Hoon} and Chin, {Young Won}",

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AU - Chae, Hee Sung

AU - Yoo, Hunseung

AU - Kim, Young Mi

AU - Choi, Young Hee

AU - Lee, Chang Hoon

AU - Chin, Young Won

PY - 2016/8/1

Y1 - 2016/8/1

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AB - The anti-inflammatory effects and molecular mechanism of 6,8-diprenyl-7,4′-dihydroxyflavanone (DDF), one of the flavanones found in Sophora tonkinensis, were assessed in vitro through macrophage-mediated inflammation in the present study. The anti-inflammatory effects of DDF were not previously reported. DDF inhibited the production of nitric oxide and the expression of tumor necrosis factor α, interleukin-1β, and interleukin-6. Furthermore, the activation of nuclear factor-κB (NF-κB) and extracellular signal-regulated kinases (ERKs) in lipopolysaccharide-stimulated macrophages was suppressed by treatment with DDF. Therefore, DDF demonstrated potentially anti-inflammatory effects via the blockade of NF-κB and ERK activation in macrophages.

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KW - Anti-inflammatory;

KW - Extracellular signal-regulated kinases

KW - Nuclear factor-κB;

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Anti-inflammatory effects of 6,8-diprenyl-7,4′-dihydroxyflavanone from Sophora tonkinensis on lipopolysaccharide-stimulated RAW 264.7 cells

Abstract

Keywords

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