Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

Soo Jin Choi; Go Eun Choi; Jae Min Oh; Yeon Ji Oh; Myung Chul Park; Jin Ho Choy

doi:10.1039/b925831k

Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

Soo Jin Choi, Go Eun Choi, Jae Min Oh, Yeon Ji Oh, Myung Chul Park, Jin Ho Choy

Department of Energy and Materials Engineering

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries.

Original language	English
Pages (from-to)	9463-9469
Number of pages	7
Journal	Journal of Materials Chemistry
Volume	20
Issue number	42
DOIs	https://doi.org/10.1039/b925831k
State	Published - 14 Nov 2010

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title = "Anticancer drug encapsulated in inorganic lattice can overcome drug resistance",

abstract = "A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries.",

author = "Choi, {Soo Jin} and Choi, {Go Eun} and Oh, {Jae Min} and Oh, {Yeon Ji} and Park, {Myung Chul} and Choy, {Jin Ho}",

year = "2010",

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doi = "10.1039/b925831k",

language = "English",

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T1 - Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

AU - Choi, Soo Jin

AU - Choi, Go Eun

AU - Oh, Jae Min

AU - Oh, Yeon Ji

AU - Park, Myung Chul

AU - Choy, Jin Ho

PY - 2010/11/14

Y1 - 2010/11/14

N2 - A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries.

AB - A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries.

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U2 - 10.1039/b925831k

DO - 10.1039/b925831k

M3 - Article

AN - SCOPUS:78049255413

SN - 0959-9428

VL - 20

SP - 9463

EP - 9469

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 42

ER -

Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

Abstract

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