Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

Soo Jin Choi; Go Eun Choi; Jae Min Oh; Yeon Ji Oh; Myung Chul Park; Jin Ho Choy

doi:10.1039/b925831k

Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

Soo Jin Choi
, Go Eun Choi
, Jae Min Oh
, Yeon Ji Oh
, Myung Chul Park
, Jin Ho Choy

Department of Energy and Materials Engineering

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries.

Original language	English
Pages (from-to)	9463-9469
Number of pages	7
Journal	Journal of Materials Chemistry
Volume	20
Issue number	42
DOIs	https://doi.org/10.1039/b925831k
State	Published - 14 Nov 2010

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title = "Anticancer drug encapsulated in inorganic lattice can overcome drug resistance",

abstract = "A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries.",

author = "Choi, \{Soo Jin\} and Choi, \{Go Eun\} and Oh, \{Jae Min\} and Oh, \{Yeon Ji\} and Park, \{Myung Chul\} and Choy, \{Jin Ho\}",

year = "2010",

month = nov,

day = "14",

doi = "10.1039/b925831k",

language = "English",

volume = "20",

pages = "9463--9469",

journal = "Journal of Materials Chemistry",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

AU - Choi, Soo Jin

AU - Choi, Go Eun

AU - Oh, Jae Min

AU - Oh, Yeon Ji

AU - Park, Myung Chul

AU - Choy, Jin Ho

PY - 2010/11/14

Y1 - 2010/11/14

N2 - A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries.

AB - A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries.

UR - https://www.scopus.com/pages/publications/78049255413

U2 - 10.1039/b925831k

DO - 10.1039/b925831k

M3 - Article

AN - SCOPUS:78049255413

SN - 0959-9428

VL - 20

SP - 9463

EP - 9469

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 42

ER -

Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

Abstract

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