Antioxidant activity of dihydrofurocoumarins from Corydalis heterocarpa

You Ah Kim; Jung Im Lee; Chang Suk Kong; Joong Chul Choe; Kwang suk Oh; Youngwan Seo

doi:10.1007/s12257-014-0462-1

Antioxidant activity of dihydrofurocoumarins from Corydalis heterocarpa

You Ah Kim, Jung Im Lee, Chang Suk Kong, Joong Chul Choe, Kwang suk Oh, Youngwan Seo

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The aim of this paper is to report the results of investigations into the antioxidant effect of dihydrofurocoumarins (1–6), isolated from the salt marsh plant Corydalis heterocarpa. The scavenging activities of the isolated compounds against DPPH radicals, hydroxyl radicals, and superoxide radicals were evaluated by electron spin resonance. The protective activities of these compounds against hydroxyl radical-mediated genomic DNA damage and peroxynitrite-mediated dihydrorhodamine oxidation were also investigated. The experimental results show that most compounds had antioxidant activity but their capabilities differed a little for the different indicators. Among them, compound 6 exerted the strongest antioxidant activity at a concentration of 100 μM/mL for all tested bioassay systems, compared with other compounds.

Original language	English
Pages (from-to)	771-779
Number of pages	9
Journal	Biotechnology and Bioprocess Engineering
Volume	19
Issue number	5
DOIs	https://doi.org/10.1007/s12257-014-0462-1
State	Published - 20 Nov 2014

Keywords

antioxidant
Corydalis heterocarpa
coumarin
DNA oxidation
reactive oxygen species (ROS)

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10.1007/s12257-014-0462-1

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title = "Antioxidant activity of dihydrofurocoumarins from Corydalis heterocarpa",

abstract = "The aim of this paper is to report the results of investigations into the antioxidant effect of dihydrofurocoumarins (1–6), isolated from the salt marsh plant Corydalis heterocarpa. The scavenging activities of the isolated compounds against DPPH radicals, hydroxyl radicals, and superoxide radicals were evaluated by electron spin resonance. The protective activities of these compounds against hydroxyl radical-mediated genomic DNA damage and peroxynitrite-mediated dihydrorhodamine oxidation were also investigated. The experimental results show that most compounds had antioxidant activity but their capabilities differed a little for the different indicators. Among them, compound 6 exerted the strongest antioxidant activity at a concentration of 100 μM/mL for all tested bioassay systems, compared with other compounds.",

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AU - Kim, You Ah

AU - Lee, Jung Im

AU - Kong, Chang Suk

AU - Choe, Joong Chul

AU - Oh, Kwang suk

AU - Seo, Youngwan

PY - 2014/11/20

Y1 - 2014/11/20

N2 - The aim of this paper is to report the results of investigations into the antioxidant effect of dihydrofurocoumarins (1–6), isolated from the salt marsh plant Corydalis heterocarpa. The scavenging activities of the isolated compounds against DPPH radicals, hydroxyl radicals, and superoxide radicals were evaluated by electron spin resonance. The protective activities of these compounds against hydroxyl radical-mediated genomic DNA damage and peroxynitrite-mediated dihydrorhodamine oxidation were also investigated. The experimental results show that most compounds had antioxidant activity but their capabilities differed a little for the different indicators. Among them, compound 6 exerted the strongest antioxidant activity at a concentration of 100 μM/mL for all tested bioassay systems, compared with other compounds.

AB - The aim of this paper is to report the results of investigations into the antioxidant effect of dihydrofurocoumarins (1–6), isolated from the salt marsh plant Corydalis heterocarpa. The scavenging activities of the isolated compounds against DPPH radicals, hydroxyl radicals, and superoxide radicals were evaluated by electron spin resonance. The protective activities of these compounds against hydroxyl radical-mediated genomic DNA damage and peroxynitrite-mediated dihydrorhodamine oxidation were also investigated. The experimental results show that most compounds had antioxidant activity but their capabilities differed a little for the different indicators. Among them, compound 6 exerted the strongest antioxidant activity at a concentration of 100 μM/mL for all tested bioassay systems, compared with other compounds.

KW - antioxidant

KW - Corydalis heterocarpa

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KW - DNA oxidation

KW - reactive oxygen species (ROS)

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Antioxidant activity of dihydrofurocoumarins from Corydalis heterocarpa

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