TY - JOUR
T1 - Antioxidant activity of isoacteoside from Clerodendron trichotomum
AU - Chae, Sungwook
AU - Kim, Ju Sun
AU - Kang, Kyoung Ah
AU - Bu, Hyung Deuk
AU - Lee, Youngki
AU - Seo, Young Rok
AU - Hyun, Jin Won
AU - Kang, Sam Sik
PY - 2005/3/12
Y1 - 2005/3/12
N2 - The antioxidant properties of isoacteoside, isolated from Clerodendron trichotomum (Verbenaceae), were investigated. This compound scavenged intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and prevented lipid peroxidation. This radical scavenging activity of isoacteoside protected cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O 2). Furthermore, isoacteoside reduced the apoptotic cells formation induced by H2O2, as demonstrated by the decreased number of sufa-G1 hypo-diploid cells and apoptotic cell body formation. However, isoacteoside increased the activities of cellular antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Taken together, these findings suggest that isoacteoside, isolated from C. trichotomum, possesses antioxidant properties.
AB - The antioxidant properties of isoacteoside, isolated from Clerodendron trichotomum (Verbenaceae), were investigated. This compound scavenged intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and prevented lipid peroxidation. This radical scavenging activity of isoacteoside protected cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O 2). Furthermore, isoacteoside reduced the apoptotic cells formation induced by H2O2, as demonstrated by the decreased number of sufa-G1 hypo-diploid cells and apoptotic cell body formation. However, isoacteoside increased the activities of cellular antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Taken together, these findings suggest that isoacteoside, isolated from C. trichotomum, possesses antioxidant properties.
UR - http://www.scopus.com/inward/record.url?scp=12544257301&partnerID=8YFLogxK
U2 - 10.1080/15287390590900750
DO - 10.1080/15287390590900750
M3 - Article
C2 - 15799629
AN - SCOPUS:12544257301
SN - 1528-7394
VL - 68
SP - 389
EP - 400
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 5
ER -