Antioxidant activity of isoacteoside from Clerodendron trichotomum

Sungwook Chae, Ju Sun Kim, Kyoung Ah Kang, Hyung Deuk Bu, Youngki Lee, Young Rok Seo, Jin Won Hyun, Sam Sik Kang

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The antioxidant properties of isoacteoside, isolated from Clerodendron trichotomum (Verbenaceae), were investigated. This compound scavenged intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and prevented lipid peroxidation. This radical scavenging activity of isoacteoside protected cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O 2). Furthermore, isoacteoside reduced the apoptotic cells formation induced by H2O2, as demonstrated by the decreased number of sufa-G1 hypo-diploid cells and apoptotic cell body formation. However, isoacteoside increased the activities of cellular antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Taken together, these findings suggest that isoacteoside, isolated from C. trichotomum, possesses antioxidant properties.

Original languageEnglish
Pages (from-to)389-400
Number of pages12
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume68
Issue number5
DOIs
StatePublished - 12 Mar 2005

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