TY - JOUR
T1 - Antioxidant and α-glucosidase inhibitory phenolic constituents of Lactuca indica L.
AU - Choi, Chang Ik
AU - Eom, Hee Jeong
AU - Kim, Ki Hyun
N1 - Publisher Copyright:
© 2016, Pleiades Publishing, Ltd.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Lactuca indica L. (Compositae) has been used as a folk medicine for the treatment of intestinal disorders. Phytochemical constituents of L. indica were investigated, and their antioxidant and α-glucosidase inhibitory activities thoroughly studied. A phytochemical investigation of the aerial parts of L. indica resulted in the isolation and identification of eight phenolic compounds. The structures of the compounds were elucidated on the basis of spectroscopic evidence as apigenin, luteolin, isoquercitrin, chlorogenic acid, protocatechuic acid, p-hydroxymethyl benzoic acid, trans-cinnamic acid, and p-coumaric acid. Luteolin, isoquercitrin, chlorogenic acid, and p-hydroxymethyl benzoic acid showed antioxidant activities with IC50 values in the range of 35.5–52.5 μM. In addition, apigenin and luteolin showed α-glucosidase inhibition activities with IC50 values of 96.4 and 100.7 μM, respectively. These findings strongly suggest that L. indica is a potential source of natural antioxidants and/or anti-diabetic agents in pharmaceutical and health functional foods.
AB - Lactuca indica L. (Compositae) has been used as a folk medicine for the treatment of intestinal disorders. Phytochemical constituents of L. indica were investigated, and their antioxidant and α-glucosidase inhibitory activities thoroughly studied. A phytochemical investigation of the aerial parts of L. indica resulted in the isolation and identification of eight phenolic compounds. The structures of the compounds were elucidated on the basis of spectroscopic evidence as apigenin, luteolin, isoquercitrin, chlorogenic acid, protocatechuic acid, p-hydroxymethyl benzoic acid, trans-cinnamic acid, and p-coumaric acid. Luteolin, isoquercitrin, chlorogenic acid, and p-hydroxymethyl benzoic acid showed antioxidant activities with IC50 values in the range of 35.5–52.5 μM. In addition, apigenin and luteolin showed α-glucosidase inhibition activities with IC50 values of 96.4 and 100.7 μM, respectively. These findings strongly suggest that L. indica is a potential source of natural antioxidants and/or anti-diabetic agents in pharmaceutical and health functional foods.
KW - antioxidant
KW - flavonoids
KW - Lactuca indica (Compositae)
KW - α-glucosidase inhibition
UR - http://www.scopus.com/inward/record.url?scp=84974604266&partnerID=8YFLogxK
U2 - 10.1134/S1068162016030079
DO - 10.1134/S1068162016030079
M3 - Article
AN - SCOPUS:84974604266
SN - 1068-1620
VL - 42
SP - 310
EP - 315
JO - Russian Journal of Bioorganic Chemistry
JF - Russian Journal of Bioorganic Chemistry
IS - 3
ER -