Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng

Young Sam Keum; Kwang Kyun Park; Jong Min Lee; Kyung Soo Chun; Jeong Hill Park; Seung Ki Lee; Hoonjeong Kwon; Young Joon Surh

doi:10.1016/S0304-3835(99)00369-9

Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng

Young Sam Keum
, Kwang Kyun Park
, Jong Min Lee
, Kyung Soo Chun
, Jeong Hill Park
, Seung Ki Lee
, Hoonjeong Kwon
, Young Joon Surh

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

352 Scopus citations

Abstract

Heat treatment of Panax ginseng C.A. Meyer at a temperature higher than that applied to the conventional preparation of red ginseng yielded a mixture of saponins with potent antioxidative properties. Thus, the methanol extract of heat-processed neo-ginseng (designated as 'NGMe') attenuated lipid peroxidation in rat brain homogenates induced by ferric ion or ferric ion plus ascorbic acid. Furthermore, the extract protected against strand scission in φX174 supercoiled DNA induced by UV photolysis of H₂O₂, and was also capable of scavenging superoxide generated by xanthine-xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. Topical application of NGMe onto shaven backs of female ICR mice 10 min prior to TPA, significantly ameliorated skin papillomagenesis initiated by 7,12- dimethylbenz[a]anthracene. Moreover, TPA-induced enhancement of epidermal ornithine decarboxylase (ODC) activity and ODC mRNA expression was abolished by a topical dose (0.68 mg) of NGMe. Likewise, TPA-induced production of tumor necrosis factor- in mouse skin was inhibited by NGMe pretreatment. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	41-48
Number of pages	8
Journal	Cancer Letters
Volume	150
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(99)00369-9
State	Published - 13 Mar 2000

Keywords

Anti-tumor promotion
Antioxidant
Ginseng
Mouse skin carcinogenesis
Ornithine decarboxylase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(99)00369-9

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title = "Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng",

abstract = "Heat treatment of Panax ginseng C.A. Meyer at a temperature higher than that applied to the conventional preparation of red ginseng yielded a mixture of saponins with potent antioxidative properties. Thus, the methanol extract of heat-processed neo-ginseng (designated as 'NGMe') attenuated lipid peroxidation in rat brain homogenates induced by ferric ion or ferric ion plus ascorbic acid. Furthermore, the extract protected against strand scission in φX174 supercoiled DNA induced by UV photolysis of H2O2, and was also capable of scavenging superoxide generated by xanthine-xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. Topical application of NGMe onto shaven backs of female ICR mice 10 min prior to TPA, significantly ameliorated skin papillomagenesis initiated by 7,12- dimethylbenz[a]anthracene. Moreover, TPA-induced enhancement of epidermal ornithine decarboxylase (ODC) activity and ODC mRNA expression was abolished by a topical dose (0.68 mg) of NGMe. Likewise, TPA-induced production of tumor necrosis factor- in mouse skin was inhibited by NGMe pretreatment. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Anti-tumor promotion, Antioxidant, Ginseng, Mouse skin carcinogenesis, Ornithine decarboxylase",

author = "Keum, \{Young Sam\} and Park, \{Kwang Kyun\} and Lee, \{Jong Min\} and Chun, \{Kyung Soo\} and Park, \{Jeong Hill\} and Lee, \{Seung Ki\} and Hoonjeong Kwon and Surh, \{Young Joon\}",

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T1 - Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng

AU - Keum, Young Sam

AU - Park, Kwang Kyun

AU - Lee, Jong Min

AU - Chun, Kyung Soo

AU - Park, Jeong Hill

AU - Lee, Seung Ki

AU - Kwon, Hoonjeong

AU - Surh, Young Joon

PY - 2000/3/13

Y1 - 2000/3/13

N2 - Heat treatment of Panax ginseng C.A. Meyer at a temperature higher than that applied to the conventional preparation of red ginseng yielded a mixture of saponins with potent antioxidative properties. Thus, the methanol extract of heat-processed neo-ginseng (designated as 'NGMe') attenuated lipid peroxidation in rat brain homogenates induced by ferric ion or ferric ion plus ascorbic acid. Furthermore, the extract protected against strand scission in φX174 supercoiled DNA induced by UV photolysis of H2O2, and was also capable of scavenging superoxide generated by xanthine-xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. Topical application of NGMe onto shaven backs of female ICR mice 10 min prior to TPA, significantly ameliorated skin papillomagenesis initiated by 7,12- dimethylbenz[a]anthracene. Moreover, TPA-induced enhancement of epidermal ornithine decarboxylase (ODC) activity and ODC mRNA expression was abolished by a topical dose (0.68 mg) of NGMe. Likewise, TPA-induced production of tumor necrosis factor- in mouse skin was inhibited by NGMe pretreatment. (C) 2000 Elsevier Science Ireland Ltd.

AB - Heat treatment of Panax ginseng C.A. Meyer at a temperature higher than that applied to the conventional preparation of red ginseng yielded a mixture of saponins with potent antioxidative properties. Thus, the methanol extract of heat-processed neo-ginseng (designated as 'NGMe') attenuated lipid peroxidation in rat brain homogenates induced by ferric ion or ferric ion plus ascorbic acid. Furthermore, the extract protected against strand scission in φX174 supercoiled DNA induced by UV photolysis of H2O2, and was also capable of scavenging superoxide generated by xanthine-xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. Topical application of NGMe onto shaven backs of female ICR mice 10 min prior to TPA, significantly ameliorated skin papillomagenesis initiated by 7,12- dimethylbenz[a]anthracene. Moreover, TPA-induced enhancement of epidermal ornithine decarboxylase (ODC) activity and ODC mRNA expression was abolished by a topical dose (0.68 mg) of NGMe. Likewise, TPA-induced production of tumor necrosis factor- in mouse skin was inhibited by NGMe pretreatment. (C) 2000 Elsevier Science Ireland Ltd.

KW - Anti-tumor promotion

KW - Antioxidant

KW - Ginseng

KW - Mouse skin carcinogenesis

KW - Ornithine decarboxylase

UR - https://www.scopus.com/pages/publications/0034047551

U2 - 10.1016/S0304-3835(99)00369-9

DO - 10.1016/S0304-3835(99)00369-9

M3 - Article

C2 - 10755385

AN - SCOPUS:0034047551

SN - 0304-3835

VL - 150

SP - 41

EP - 48

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng

Abstract

Keywords

UN SDGs

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