TY - JOUR
T1 - Apolipoprotein B and non-HDL cholesterol are more powerful predictors for incident type 2 diabetes than fasting glucose or glycated hemoglobin in subjects with normal glucose tolerance
T2 - a 3.3-year retrospective longitudinal study
AU - Hwang, You Cheol
AU - Ahn, Hong Yup
AU - Park, Sung Woo
AU - Park, Cheol Young
N1 - Publisher Copyright:
© 2014, Springer-Verlag Italia.
PY - 2014/11/21
Y1 - 2014/11/21
N2 - The association between atherogenic dyslipidemia (AD) and incident type 2 diabetes (T2D) in the low-risk group for T2D has not yet been determined. The aims of this study were to investigate whether AD, characterized by increased serum apoB and non-HDL cholesterol, could predict the development of T2D in subjects with normal glucose tolerance (NGT). A total of 84,394 subjects with NGT (48,906 men and 35,488 women), aged 20–89 years (mean age 38.4 years), were enrolled in this study and were followed for a mean duration of 3.3 years. ApoB and non-HDL cholesterol levels showed stronger associations with the development of T2D compared with conventional lipid measurements and their ratios (HR per 1-SD (95 % CI) 1.27 (1.23–1.30) and 1.27 (1.24–1.29), respectively, both P < 0.001). In multivariate Cox regression models, both apoB and non-HDL cholesterol were associated with the development of T2D, independent of other risk factors for T2D, fasting serum glucose, HbA1c, and conventional lipid measurements such as triglycerides and HDL cholesterol (HR per 1-SD (95 % CI) 1.16 (1.11–1.21) and 1.15 (1.11–1.19), respectively, both P < 0.001). However, fasting serum glucose was not associated with the development of T2D in these models. In conclusion, AD was more closely associated with the development of T2D than fasting glucose or glycated hemoglobin in subjects with NGT.
AB - The association between atherogenic dyslipidemia (AD) and incident type 2 diabetes (T2D) in the low-risk group for T2D has not yet been determined. The aims of this study were to investigate whether AD, characterized by increased serum apoB and non-HDL cholesterol, could predict the development of T2D in subjects with normal glucose tolerance (NGT). A total of 84,394 subjects with NGT (48,906 men and 35,488 women), aged 20–89 years (mean age 38.4 years), were enrolled in this study and were followed for a mean duration of 3.3 years. ApoB and non-HDL cholesterol levels showed stronger associations with the development of T2D compared with conventional lipid measurements and their ratios (HR per 1-SD (95 % CI) 1.27 (1.23–1.30) and 1.27 (1.24–1.29), respectively, both P < 0.001). In multivariate Cox regression models, both apoB and non-HDL cholesterol were associated with the development of T2D, independent of other risk factors for T2D, fasting serum glucose, HbA1c, and conventional lipid measurements such as triglycerides and HDL cholesterol (HR per 1-SD (95 % CI) 1.16 (1.11–1.21) and 1.15 (1.11–1.19), respectively, both P < 0.001). However, fasting serum glucose was not associated with the development of T2D in these models. In conclusion, AD was more closely associated with the development of T2D than fasting glucose or glycated hemoglobin in subjects with NGT.
KW - Apolipoprotein B
KW - Non-HDL cholesterol
KW - Normal glucose tolerance
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84919448323&partnerID=8YFLogxK
U2 - 10.1007/s00592-014-0587-x
DO - 10.1007/s00592-014-0587-x
M3 - Article
C2 - 24816996
AN - SCOPUS:84919448323
SN - 0940-5429
VL - 51
SP - 941
EP - 946
JO - Acta Diabetologica
JF - Acta Diabetologica
IS - 6
ER -