TY - JOUR
T1 - Application of diethylene glycol monoethyl ether in solubilization of poorly water-soluble drugs
AU - Ha, Eun Sol
AU - Lee, Seon Kwang
AU - Choi, Du Hyung
AU - Jeong, Seong Hoon
AU - Hwang, Sung Joo
AU - Kim, Min Soo
N1 - Publisher Copyright:
© 2019, The Korean Society of Pharmaceutical Sciences and Technology.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Background: Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. It has been used as a pharmaceutical solvent for many years under the trade name transcutol. DEGEE, a hydroalcoholic solvent, is gaining interest as a penetration/permeation enhancer, solubilizer, and surfactant for drug delivery systems. Area covered: The physicochemical properties of DEGEE, the solubility data for drugs in DEGEE or DEGEE-water mixtures, and the applications of DEGEE in the solubilization of poorly water-soluble drugs are summarized in this review. Expert opinion: DEGEE is a promising excipient as a solubilizer for many pharmaceutical products with enhanced drug absorption via oral, parenteral, and topical administration, as well as cosmetic products.
AB - Background: Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. It has been used as a pharmaceutical solvent for many years under the trade name transcutol. DEGEE, a hydroalcoholic solvent, is gaining interest as a penetration/permeation enhancer, solubilizer, and surfactant for drug delivery systems. Area covered: The physicochemical properties of DEGEE, the solubility data for drugs in DEGEE or DEGEE-water mixtures, and the applications of DEGEE in the solubilization of poorly water-soluble drugs are summarized in this review. Expert opinion: DEGEE is a promising excipient as a solubilizer for many pharmaceutical products with enhanced drug absorption via oral, parenteral, and topical administration, as well as cosmetic products.
KW - Cosolvent
KW - Diethylene glycol monoethyl ether
KW - Solubility
KW - Solubilizer
KW - Transcutol
UR - http://www.scopus.com/inward/record.url?scp=85067253833&partnerID=8YFLogxK
U2 - 10.1007/s40005-019-00454-y
DO - 10.1007/s40005-019-00454-y
M3 - Review article
AN - SCOPUS:85067253833
SN - 2093-5552
VL - 50
SP - 231
EP - 250
JO - Journal of Pharmaceutical Investigation
JF - Journal of Pharmaceutical Investigation
IS - 3
ER -