(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

Kyeong Lee; Jeong Hyung Lee; Shanthaveerappa K. Boovanahalli; Yinglan Jin; Mijeoung Lee; Xuejun Jin; Jin Hwan Kim; Young Soo Hong; Jung Joon Lee

doi:10.1021/jm0610292

(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

Kyeong Lee, Jeong Hyung Lee, Shanthaveerappa K. Boovanahalli, Yinglan Jin, Mijeoung Lee, Xuejun Jin, Jin Hwan Kim, Young Soo Hong, Jung Joon Lee

Department of Pharmacy

Korea Research Institute of Bioscience and Biotechnology

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

Original language	English
Pages (from-to)	1675-1684
Number of pages	10
Journal	Journal of Medicinal Chemistry
Volume	50
Issue number	7
DOIs	https://doi.org/10.1021/jm0610292
State	Published - 5 Apr 2007

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title = "(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors",

abstract = "Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.",

author = "Kyeong Lee and Lee, {Jeong Hyung} and Boovanahalli, {Shanthaveerappa K.} and Yinglan Jin and Mijeoung Lee and Xuejun Jin and Kim, {Jin Hwan} and Hong, {Young Soo} and Lee, {Jung Joon}",

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doi = "10.1021/jm0610292",

language = "English",

volume = "50",

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journal = "Journal of Medicinal Chemistry",

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T1 - (Aryloxyacetylamino)benzoic acid analogues

T2 - A new class of hypoxia-inducible factor-1 inhibitors

AU - Lee, Kyeong

AU - Lee, Jeong Hyung

AU - Boovanahalli, Shanthaveerappa K.

AU - Jin, Yinglan

AU - Lee, Mijeoung

AU - Jin, Xuejun

AU - Kim, Jin Hwan

AU - Hong, Young Soo

AU - Lee, Jung Joon

PY - 2007/4/5

Y1 - 2007/4/5

N2 - Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

AB - Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

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U2 - 10.1021/jm0610292

DO - 10.1021/jm0610292

M3 - Article

C2 - 17328532

AN - SCOPUS:34147145911

SN - 0022-2623

VL - 50

SP - 1675

EP - 1684

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 7

ER -

(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

Abstract

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