(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

Kyeong Lee; Jeong Hyung Lee; Shanthaveerappa K. Boovanahalli; Yinglan Jin; Mijeoung Lee; Xuejun Jin; Jin Hwan Kim; Young Soo Hong; Jung Joon Lee

doi:10.1021/jm0610292

(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

Kyeong Lee
, Jeong Hyung Lee
, Shanthaveerappa K. Boovanahalli
, Yinglan Jin
, Mijeoung Lee
, Xuejun Jin
, Jin Hwan Kim
, Young Soo Hong
, Jung Joon Lee

Department of Pharmacy

Korea Research Institute of Bioscience and Biotechnology

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

Original language	English
Pages (from-to)	1675-1684
Number of pages	10
Journal	Journal of Medicinal Chemistry
Volume	50
Issue number	7
DOIs	https://doi.org/10.1021/jm0610292
State	Published - 5 Apr 2007

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10.1021/jm0610292

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title = "(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors",

abstract = "Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.",

author = "Kyeong Lee and Lee, \{Jeong Hyung\} and Boovanahalli, \{Shanthaveerappa K.\} and Yinglan Jin and Mijeoung Lee and Xuejun Jin and Kim, \{Jin Hwan\} and Hong, \{Young Soo\} and Lee, \{Jung Joon\}",

year = "2007",

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doi = "10.1021/jm0610292",

language = "English",

volume = "50",

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journal = "Journal of Medicinal Chemistry",

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T1 - (Aryloxyacetylamino)benzoic acid analogues

T2 - A new class of hypoxia-inducible factor-1 inhibitors

AU - Lee, Kyeong

AU - Lee, Jeong Hyung

AU - Boovanahalli, Shanthaveerappa K.

AU - Jin, Yinglan

AU - Lee, Mijeoung

AU - Jin, Xuejun

AU - Kim, Jin Hwan

AU - Hong, Young Soo

AU - Lee, Jung Joon

PY - 2007/4/5

Y1 - 2007/4/5

N2 - Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

AB - Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

UR - https://www.scopus.com/pages/publications/34147145911

U2 - 10.1021/jm0610292

DO - 10.1021/jm0610292

M3 - Article

C2 - 17328532

AN - SCOPUS:34147145911

SN - 0022-2623

VL - 50

SP - 1675

EP - 1684

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 7

ER -

(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

Abstract

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