TY - JOUR
T1 - Association between diabetes and asthma
T2 - Evidence from a nationwide Korean study
AU - taskforce team of Diabetes Fact Sheet of the Korean Diabetes Association
AU - Baek, Ji Yeon
AU - Lee, Seung Eun
AU - Han, Kyungdo
AU - Koh, Eun Hee
N1 - Publisher Copyright:
© 2018 American College of Allergy, Asthma 8 Immunology
PY - 2018/12
Y1 - 2018/12
N2 - Background: Type 2 diabetes and asthma share a common pathophysiology: “chronic inflammation.” However, it is unclear whether patients with type 2 diabetes are at increased risk of asthma. Objective: To investigate the effect of type 2 diabetes on asthma using data from a large population-based study in Korea. Methods: Data from the Korean National Health Insurance Service identified 13,154,348 participants who underwent regular health checkups from 2005 to 2008. Subjects were classified according to status of diabetes mellitus (DM) and diabetic retinopathy (DR), and followed until the date of asthma development, death, or December 31, 2013. Cox proportional hazard regression analysis was used to evaluate the effect of diabetes, with or without retinopathy, on asthma development. Results: The incidences of asthma in the non-DM, DM without DR, and DR groups were 27.1, 30.1, and 38.4 per 1,000 person-years, respectively. Cox proportional hazard multiple regression models revealed that diabetic patients without retinopathy had a significantly lower risk of developing asthma than non-DM subjects (hazard ratio, 0.943; 95% confidence interval, 0.939-0.948). By contrast, diabetic patients with retinopathy had a higher risk of developing asthma (hazard ratio, 1.067; 95% confidence interval, 1.053-1.081). Conclusion: Type 2 diabetes without retinopathy is not a risk factor for asthma development. However, patients with DR are at a greater risk of incident asthma, supporting the notion that the lung is a target organ for diabetic injury. Future studies will address whether proper glycemic control mitigates the risk of asthma.
AB - Background: Type 2 diabetes and asthma share a common pathophysiology: “chronic inflammation.” However, it is unclear whether patients with type 2 diabetes are at increased risk of asthma. Objective: To investigate the effect of type 2 diabetes on asthma using data from a large population-based study in Korea. Methods: Data from the Korean National Health Insurance Service identified 13,154,348 participants who underwent regular health checkups from 2005 to 2008. Subjects were classified according to status of diabetes mellitus (DM) and diabetic retinopathy (DR), and followed until the date of asthma development, death, or December 31, 2013. Cox proportional hazard regression analysis was used to evaluate the effect of diabetes, with or without retinopathy, on asthma development. Results: The incidences of asthma in the non-DM, DM without DR, and DR groups were 27.1, 30.1, and 38.4 per 1,000 person-years, respectively. Cox proportional hazard multiple regression models revealed that diabetic patients without retinopathy had a significantly lower risk of developing asthma than non-DM subjects (hazard ratio, 0.943; 95% confidence interval, 0.939-0.948). By contrast, diabetic patients with retinopathy had a higher risk of developing asthma (hazard ratio, 1.067; 95% confidence interval, 1.053-1.081). Conclusion: Type 2 diabetes without retinopathy is not a risk factor for asthma development. However, patients with DR are at a greater risk of incident asthma, supporting the notion that the lung is a target organ for diabetic injury. Future studies will address whether proper glycemic control mitigates the risk of asthma.
UR - http://www.scopus.com/inward/record.url?scp=85056867008&partnerID=8YFLogxK
U2 - 10.1016/j.anai.2018.08.008
DO - 10.1016/j.anai.2018.08.008
M3 - Article
C2 - 30134180
AN - SCOPUS:85056867008
SN - 1081-1206
VL - 121
SP - 699
EP - 703
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 6
ER -