Association of CDKN2B-AS and WNT4 genetic polymorphisms in Korean patients with endometriosis

Gyoung Hoon Lee, Young Min Choi, Min A. Hong, Sang Ho Yoon, Jin Ju Kim, Kyuri Hwang, Soo Jin Chae

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Objective: To investigate whether specific genetic polymorphisms in the cyclin-dependent kinase inhibitor 2B antisense RNA (CDKN2B-AS) gene and near the wingless-type MMTV integration site family member 4 (WNT4) gene are associated with endometriosis in a Korean population. Design: Case-control genetic association study. Setting: University. Patient(s): Surgically or histologically diagnosed cases of endometriosis (n = 673) and controls (n = 500) among a population of ethnic Koreans. Intervention(s): None. Main Outcome Measure(s): Genotype distribution and synergistic interaction. Result(s): Significant differences were found in the allele distributions of the CC genotype of the rs10965235 single-nucleotide polymorphism (SNP) of the CDKN2B-AS gene and the GG genotype of the rs16826658 SNP on chromosome 1p36 between the endometriosis cases and the controls (rs10965235: 69.7% CC, 26.9% CA, and 3.4% AA vs. 59.2% CC, 35.2% CA, and 5.6% AA; rs16826658: 33.7% GG, 48.4% GT, and 17.8% TT vs. 25.6% GG, 49.8% GT, and 24.6% TT, respectively). A signi ficant interaction was not found between the CC genotype of the rs10965235 SNP and the GG genotype of the rs16826658 SNP after Bonferroni correction (32.8% of CC + GG and 67.2% of CC + non-GG in the endometriosis cases vs. 25.0% of CC + GG and 75.0% of CC + non-GG in the controls). Conclusion(s): Our results suggest that the rs10965235 SNP in the CDKN2B-AS gene and the rs16826658 SNP near the WNT4 gene were signi ficantly associated with endometriosis in this Korean population.

Original languageEnglish
Pages (from-to)1393-1397
Number of pages5
JournalFertility and Sterility
Volume102
Issue number5
DOIs
StatePublished - 2014

Keywords

  • CDKN2B-AS
  • Endometriosis
  • Polymorphism
  • WNT4

Fingerprint

Dive into the research topics of 'Association of CDKN2B-AS and WNT4 genetic polymorphisms in Korean patients with endometriosis'. Together they form a unique fingerprint.

Cite this