Association of the catechol O-methyltransferase Val158-met polymorphism and reduced interference control in korean children with attention-deficit hyperactivity disorder

Subin Park; Jong Eun Park; Hee Jeong Yoo; Jae Won Kim; Jae Hoon Cheong; Doug Hyun Han; Yeni Kim; Bung Nyun Kim

doi:10.4306/pi.2015.12.4.563

Association of the catechol O-methyltransferase Val158-met polymorphism and reduced interference control in korean children with attention-deficit hyperactivity disorder

Subin Park, Jong Eun Park, Hee Jeong Yoo, Jae Won Kim, Jae Hoon Cheong, Doug Hyun Han, Yeni Kim, Bung Nyun Kim

Department of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objective : We tested for association of the catechol-O-methyltransferase (COMT) Val¹⁵⁸-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. Methods : A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios. Results : In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ²=4.21, p=0.040). Conclusion : These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.

Original language	English
Pages (from-to)	563-565
Number of pages	3
Journal	Psychiatry Investigation
Volume	12
Issue number	4
DOIs	https://doi.org/10.4306/pi.2015.12.4.563
State	Published - Oct 2015

Keywords

Attention-deficit hyperactivity disorder
COMT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4306/pi.2015.12.4.563

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title = "Association of the catechol O-methyltransferase Val158-met polymorphism and reduced interference control in korean children with attention-deficit hyperactivity disorder",

abstract = "Objective : We tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. Methods : A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios. Results : In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ2=4.21, p=0.040). Conclusion : These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.",

keywords = "Attention-deficit hyperactivity disorder, COMT",

author = "Subin Park and Park, {Jong Eun} and Yoo, {Hee Jeong} and Kim, {Jae Won} and Cheong, {Jae Hoon} and Han, {Doug Hyun} and Yeni Kim and Kim, {Bung Nyun}",

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year = "2015",

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doi = "10.4306/pi.2015.12.4.563",

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journal = "Psychiatry Investigation",

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T1 - Association of the catechol O-methyltransferase Val158-met polymorphism and reduced interference control in korean children with attention-deficit hyperactivity disorder

AU - Park, Subin

AU - Park, Jong Eun

AU - Yoo, Hee Jeong

AU - Kim, Jae Won

AU - Cheong, Jae Hoon

AU - Han, Doug Hyun

AU - Kim, Yeni

AU - Kim, Bung Nyun

PY - 2015/10

Y1 - 2015/10

N2 - Objective : We tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. Methods : A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios. Results : In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ2=4.21, p=0.040). Conclusion : These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.

AB - Objective : We tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. Methods : A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios. Results : In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ2=4.21, p=0.040). Conclusion : These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.

KW - Attention-deficit hyperactivity disorder

KW - COMT

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Association of the catechol O-methyltransferase Val158-met polymorphism and reduced interference control in korean children with attention-deficit hyperactivity disorder

Abstract

Keywords

UN SDGs

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