Autophagy in osteoarthritis

Hyelin Jeon, Gun Il Im

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

Osteoarthritis is characterized by continuous degeneration of articular cartilage resulting in disability. The death of chondrocytes and the loss of the extracellular matrix are the central peculiarities in cartilage degeneration during osteoarthritis pathogenesis. Autophagy is an essential cellular homeostasis mechanism whereby cellular organelles and macromolecules are recycled to maintain cellular metabolism. Autophagy is reported to be cytoprotective effects for articular cartilage, and osteoarthritis is associated with decreased autophagy. While autophagy is known to be cytoprotective to chondrocytes, its role may vary with differing stages and models of osteoarthritis. Therefore, more in-depth studies on autophagy are needed to determine its impact on cell survival and death in articular cartilage under various in vitro and in vivo conditions. Application of autophagy on osteoarthritis therapeutics will be possible after a profound understanding is established on the role of autophagy in osteoarthritis pathogenesis.

Original languageEnglish
Pages (from-to)497-508
Number of pages12
JournalConnective Tissue Research
Volume58
Issue number6
DOIs
StatePublished - 2 Nov 2017

Keywords

  • apoptosis
  • articular cartilage
  • Autophagy
  • cell survival
  • osteoarthritis

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