Baicalin encapsulating lipid-surfactant conjugate based nanomicelles: Preparation, characterization and anticancer activity

Ashok Kumar Jangid, Hina Agraval, Divya Bharti Rai, Poonam Jain, Umesh CS Yadav, Deep Pooja, Hitesh Kulhari

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Lung cancer is one of the most common malignant tumors and emerged as one of the leading causes of cancer-related death worldwide. Surgical resection can be a curative treatment for early stage but the most of lung cancer patients are diagnosed at an advanced stage when the pulmonary tumor has been invaded beyond the respiratory system. Therefore, chemotherapy is suitable for curing metastasized tumor. Baicalin (BL) is a flavonoid which has been studied in the treatment of several types of cancer including lung cancer. However, its low solubility in water and non-specificity impede its practical utilization. Hence, we have reported a stearic acid and pluronic F68 conjugated nanomicelles (PF68-SA) system to improve therapeutic efficacy of BL. Solvent evaporation method was used to prepare the BL-loaded PF68-SA nanomicelles (BLNM). The designed BLNM were characterized for the particle size, surface charge, critical micelle concentration, colloidal stability, morphology, and total drug content. BLNM formulation showed improved toxicity of BL against A549 human lung cancer cells in cytotoxicity assay. Further, apoptosis study also depicted BLNM-induced cell death in A549 cells. Therefore, the synthesized fatty acid-modified polymeric nanomicellar system could be useful in overcoming the stability and low therapeutic efficacy issues of hydrophobic anticancer drugs like BL and delivering them to the cancer cells.

Original languageEnglish
Article number104978
JournalChemistry and Physics of Lipids
Volume233
DOIs
StatePublished - Nov 2020

Keywords

  • Baicalin
  • Critical micellar concentration
  • Cytotoxicity
  • Lung cancer
  • Nanomicelles
  • Pluronic F68-steraic acid conjugate (PF68-SA)

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