Benzophenone-3 and benzophenone-8 exhibit obesogenic activity via peroxisome proliferator-activated receptor γ pathway

Jeayoung C. Shin, Eunyoung Lee, Seungchan An, Sun Hee Jin, Jaehyoun Ha, Won Jun Choi, Minsoo Noh

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Benzophenone-3 (BP-3) and benzopenone-8 (BP-8) are commonly used ultraviolet (UV) filter ingredients in diverse sunscreen products. Recently, the obesogenic activity of avobenzone, a long wave UV A filter, was elucidated in the adipogenesis model of human bone marrow mesenchymal stem cells (hBM-MSCs). In this study, the obesogenic potentials of BP-3 and BP-8 were investigated because of their chemical similarity to avobenzone. During the adipogenesis in hBM-MSCs, BP-3 and BP-8 (EC50, 25.05 and 43.20 μM, respectively) potently promoted adiponectin secretion than avobenzone (EC50, 72.69 μM). In target identification, both BP-3 and BP-8 directly bound to peroxisome proliferator-activated receptor γ (PPARγ), which was associated with the recruitment of steroid receptor coactivator-2 (SRC-2). BP-3 functioned as a PPARγ full agonist whereas BP-8 was a PPARγ partial agonist. In addition, BP-3 and BP-8 significantly increased the gene transcription of PPARα, PPARγ, and major lipid metabolism-associated enzymes in human epidermal keratinocytes, a major target site of UV filters in human skin. This study suggests that BP-3 and BP-8 are obesogenic environmental chemicals similar to phthalates, bisphenols, and organotins.

Original languageEnglish
Article number104886
JournalToxicology in Vitro
Volume67
DOIs
StatePublished - Sep 2020

Keywords

  • Benzophenone-3
  • Benzophenone-8
  • Human bone marrow mesenchymal stem cells
  • Obesogen
  • PPARγ

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