Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

Hongwon Kim; Jaein Shin; Sumin Kim; Siyoung Kim; Byounggook Cho; Sang jun Park; Gwoncheol Park; Hakdong Shin; Myeong Soo Park; Jongpil Kim

doi:10.1016/j.bbrc.2022.03.024

Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

Hongwon Kim
, Jaein Shin
, Sumin Kim
, Siyoung Kim
, Byounggook Cho
, Sang jun Park
, Gwoncheol Park
, Hakdong Shin
, Myeong Soo Park
, Jongpil Kim

Department of Chemistry

Dongguk University
Ltd
Sejong University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. bifidum BGN4 and B. longum BORI effectively elevates brain-derived neurotrophic factor expression which was mediated by increased histone 3 lysine 9 trimethylation. Furthermore, administration of probiotic supplementation reversed the DNA damage and apoptotic response in aged mice and also improved the age-related cognitive and memory deficits of these mice. Taken together, the present study highlights the anti-aging effects of B. bifidum BGN4 and B. longum BORI in the aged brain and their beneficial effects for age-related brain disorders.

Original language	English
Pages (from-to)	41-48
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	603
DOIs	https://doi.org/10.1016/j.bbrc.2022.03.024
State	Published - 7 May 2022

Keywords

Aging
Bifidobacterium
Cognitive and memory impairment
Gut microbiota
Probiotics

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title = "Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice",

abstract = "An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. bifidum BGN4 and B. longum BORI effectively elevates brain-derived neurotrophic factor expression which was mediated by increased histone 3 lysine 9 trimethylation. Furthermore, administration of probiotic supplementation reversed the DNA damage and apoptotic response in aged mice and also improved the age-related cognitive and memory deficits of these mice. Taken together, the present study highlights the anti-aging effects of B. bifidum BGN4 and B. longum BORI in the aged brain and their beneficial effects for age-related brain disorders.",

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author = "Hongwon Kim and Jaein Shin and Sumin Kim and Siyoung Kim and Byounggook Cho and Park, \{Sang jun\} and Gwoncheol Park and Hakdong Shin and Park, \{Myeong Soo\} and Jongpil Kim",

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doi = "10.1016/j.bbrc.2022.03.024",

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T1 - Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

AU - Kim, Hongwon

AU - Shin, Jaein

AU - Kim, Sumin

AU - Kim, Siyoung

AU - Cho, Byounggook

AU - Park, Sang jun

AU - Park, Gwoncheol

AU - Shin, Hakdong

AU - Park, Myeong Soo

AU - Kim, Jongpil

PY - 2022/5/7

Y1 - 2022/5/7

N2 - An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. bifidum BGN4 and B. longum BORI effectively elevates brain-derived neurotrophic factor expression which was mediated by increased histone 3 lysine 9 trimethylation. Furthermore, administration of probiotic supplementation reversed the DNA damage and apoptotic response in aged mice and also improved the age-related cognitive and memory deficits of these mice. Taken together, the present study highlights the anti-aging effects of B. bifidum BGN4 and B. longum BORI in the aged brain and their beneficial effects for age-related brain disorders.

AB - An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. bifidum BGN4 and B. longum BORI effectively elevates brain-derived neurotrophic factor expression which was mediated by increased histone 3 lysine 9 trimethylation. Furthermore, administration of probiotic supplementation reversed the DNA damage and apoptotic response in aged mice and also improved the age-related cognitive and memory deficits of these mice. Taken together, the present study highlights the anti-aging effects of B. bifidum BGN4 and B. longum BORI in the aged brain and their beneficial effects for age-related brain disorders.

KW - Aging

KW - Bifidobacterium

KW - Cognitive and memory impairment

KW - Gut microbiota

KW - Probiotics

UR - https://www.scopus.com/pages/publications/85125844837

U2 - 10.1016/j.bbrc.2022.03.024

DO - 10.1016/j.bbrc.2022.03.024

M3 - Article

C2 - 35278878

AN - SCOPUS:85125844837

SN - 0006-291X

VL - 603

SP - 41

EP - 48

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

ER -

Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

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