Bio-functional Mn₂O₃-carboxymethyl cellulose-L-arginine hybrid nanomaterials for targeting Candida albicans and oral cancer

Karthikeyan Chandrasekaran; Sang Min Chung

doi:10.1016/j.ijbiomac.2025.145782

Bio-functional Mn₂O₃-carboxymethyl cellulose-L-arginine hybrid nanomaterials for targeting Candida albicans and oral cancer

Department of Life Science

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The hybrid manganese oxide (Mn₂O₃)-carboxymethyl cellulose (CMC)-L-arginine (LA) hybrid nanomaterials (HNMs) were synthesized via a one-pot method. This technique reduces reaction time, simplifies the synthesis process, and enhances scalability, making it suitable for biomedical applications. Structural, optical, and biological studies were characterized the synthesized Mn₂O₃ and Mn₂O₃-CMC-LA HNMs. The Mn₂O₃-CMC-LA HNMs demonstrated significant antifungal activity against Candida albicans and anticancer effects against oral cancer cells. Biocompatibility was confirmed using an in vivo zebrafish embryos model. These findings highlight the potential of Mn₂O₃-CMC-LA HNMs for biomedical application in fungal infection treatment and oral cancer diagnostics.

Original language	English
Article number	145782
Journal	International Journal of Biological Macromolecules
Volume	320
DOIs	https://doi.org/10.1016/j.ijbiomac.2025.145782
State	Published - Aug 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Candida albicans
Carboxymethyl cellulose
L-arginine
MnO
Oral cancer
Zebrafish embryos

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10.1016/j.ijbiomac.2025.145782

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title = "Bio-functional Mn₂O₃-carboxymethyl cellulose-L-arginine hybrid nanomaterials for targeting Candida albicans and oral cancer",

abstract = "The hybrid manganese oxide (Mn2O3)-carboxymethyl cellulose (CMC)-L-arginine (LA) hybrid nanomaterials (HNMs) were synthesized via a one-pot method. This technique reduces reaction time, simplifies the synthesis process, and enhances scalability, making it suitable for biomedical applications. Structural, optical, and biological studies were characterized the synthesized Mn2O3 and Mn2O3-CMC-LA HNMs. The Mn2O3-CMC-LA HNMs demonstrated significant antifungal activity against Candida albicans and anticancer effects against oral cancer cells. Biocompatibility was confirmed using an in vivo zebrafish embryos model. These findings highlight the potential of Mn2O3-CMC-LA HNMs for biomedical application in fungal infection treatment and oral cancer diagnostics.",

keywords = "Candida albicans, Carboxymethyl cellulose, L-arginine, MnO, Oral cancer, Zebrafish embryos",

author = "Karthikeyan Chandrasekaran and Chung, \{Sang Min\}",

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year = "2025",

month = aug,

doi = "10.1016/j.ijbiomac.2025.145782",

language = "English",

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T1 - Bio-functional Mn₂O₃-carboxymethyl cellulose-L-arginine hybrid nanomaterials for targeting Candida albicans and oral cancer

AU - Chandrasekaran, Karthikeyan

AU - Chung, Sang Min

PY - 2025/8

Y1 - 2025/8

N2 - The hybrid manganese oxide (Mn2O3)-carboxymethyl cellulose (CMC)-L-arginine (LA) hybrid nanomaterials (HNMs) were synthesized via a one-pot method. This technique reduces reaction time, simplifies the synthesis process, and enhances scalability, making it suitable for biomedical applications. Structural, optical, and biological studies were characterized the synthesized Mn2O3 and Mn2O3-CMC-LA HNMs. The Mn2O3-CMC-LA HNMs demonstrated significant antifungal activity against Candida albicans and anticancer effects against oral cancer cells. Biocompatibility was confirmed using an in vivo zebrafish embryos model. These findings highlight the potential of Mn2O3-CMC-LA HNMs for biomedical application in fungal infection treatment and oral cancer diagnostics.

AB - The hybrid manganese oxide (Mn2O3)-carboxymethyl cellulose (CMC)-L-arginine (LA) hybrid nanomaterials (HNMs) were synthesized via a one-pot method. This technique reduces reaction time, simplifies the synthesis process, and enhances scalability, making it suitable for biomedical applications. Structural, optical, and biological studies were characterized the synthesized Mn2O3 and Mn2O3-CMC-LA HNMs. The Mn2O3-CMC-LA HNMs demonstrated significant antifungal activity against Candida albicans and anticancer effects against oral cancer cells. Biocompatibility was confirmed using an in vivo zebrafish embryos model. These findings highlight the potential of Mn2O3-CMC-LA HNMs for biomedical application in fungal infection treatment and oral cancer diagnostics.

KW - Candida albicans

KW - Carboxymethyl cellulose

KW - L-arginine

KW - MnO

KW - Oral cancer

KW - Zebrafish embryos

UR - https://www.scopus.com/pages/publications/105009982827

U2 - 10.1016/j.ijbiomac.2025.145782

DO - 10.1016/j.ijbiomac.2025.145782

M3 - Article

C2 - 40633865

AN - SCOPUS:105009982827

SN - 0141-8130

VL - 320

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

M1 - 145782

ER -

Bio-functional Mn₂O₃-carboxymethyl cellulose-L-arginine hybrid nanomaterials for targeting Candida albicans and oral cancer

Abstract

UN SDGs

Keywords

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