Bioactive benzofuran derivatives: Moracins A-Z in medicinal chemistry

Ravi Naik, Dipesh S. Harmalkar, Xuezhen Xu, Kyusic Jang, Kyeong Lee

Research output: Contribution to journalReview articlepeer-review

217 Scopus citations

Abstract

Benzofuran heterocycles are fundamental structural units in a variety of biologically active natural products as well as synthetic materials. Over the time, benzofuran derivatives have attracted many researchers due to the broad scope of their biological activity, which include anticancer, antimicrobial, immunomodulatory, antioxidant and anti-inflammatory properties. Egonol, homoegonol and moracin families are biologically active natural products containing benzofuran heterocycle as basic structural units. This paper focuses on the moracin family (moracin A to Z). Morus, a genus of flowering plants in the family Moraceae, comprises 10-16 species of deciduous trees commonly known as mulberries. The root bark, stem bark and leaves of Morus alba, M. lhou, Morus macroura are the main sources for arylbenzofuran derivatives including the moracins. A large volume of research has been carried out on moracins and their derivatives, which has shown the pharmacological importance of this benzofuran heterocyclic nucleus. In this mini-review, we attempt to highlight the importance of moracins, as they have been a major source for drug development. Herein, we also summarize the current state of the art concerning the synthesis and medicinal use of moracins A-Z.

Original languageEnglish
Pages (from-to)379-393
Number of pages15
JournalEuropean Journal of Medicinal Chemistry
Volume90
DOIs
StatePublished - 27 Jan 2015

Keywords

  • Benzofuran
  • Biological activity
  • Moracins
  • Mulberries

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