TY - JOUR
T1 - Bioactive benzofuran derivatives
T2 - Moracins A-Z in medicinal chemistry
AU - Naik, Ravi
AU - Harmalkar, Dipesh S.
AU - Xu, Xuezhen
AU - Jang, Kyusic
AU - Lee, Kyeong
N1 - Publisher Copyright:
© 2014 Published by Elsevier Masson SAS.
PY - 2015/1/27
Y1 - 2015/1/27
N2 - Benzofuran heterocycles are fundamental structural units in a variety of biologically active natural products as well as synthetic materials. Over the time, benzofuran derivatives have attracted many researchers due to the broad scope of their biological activity, which include anticancer, antimicrobial, immunomodulatory, antioxidant and anti-inflammatory properties. Egonol, homoegonol and moracin families are biologically active natural products containing benzofuran heterocycle as basic structural units. This paper focuses on the moracin family (moracin A to Z). Morus, a genus of flowering plants in the family Moraceae, comprises 10-16 species of deciduous trees commonly known as mulberries. The root bark, stem bark and leaves of Morus alba, M. lhou, Morus macroura are the main sources for arylbenzofuran derivatives including the moracins. A large volume of research has been carried out on moracins and their derivatives, which has shown the pharmacological importance of this benzofuran heterocyclic nucleus. In this mini-review, we attempt to highlight the importance of moracins, as they have been a major source for drug development. Herein, we also summarize the current state of the art concerning the synthesis and medicinal use of moracins A-Z.
AB - Benzofuran heterocycles are fundamental structural units in a variety of biologically active natural products as well as synthetic materials. Over the time, benzofuran derivatives have attracted many researchers due to the broad scope of their biological activity, which include anticancer, antimicrobial, immunomodulatory, antioxidant and anti-inflammatory properties. Egonol, homoegonol and moracin families are biologically active natural products containing benzofuran heterocycle as basic structural units. This paper focuses on the moracin family (moracin A to Z). Morus, a genus of flowering plants in the family Moraceae, comprises 10-16 species of deciduous trees commonly known as mulberries. The root bark, stem bark and leaves of Morus alba, M. lhou, Morus macroura are the main sources for arylbenzofuran derivatives including the moracins. A large volume of research has been carried out on moracins and their derivatives, which has shown the pharmacological importance of this benzofuran heterocyclic nucleus. In this mini-review, we attempt to highlight the importance of moracins, as they have been a major source for drug development. Herein, we also summarize the current state of the art concerning the synthesis and medicinal use of moracins A-Z.
KW - Benzofuran
KW - Biological activity
KW - Moracins
KW - Mulberries
UR - http://www.scopus.com/inward/record.url?scp=84913582348&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2014.11.047
DO - 10.1016/j.ejmech.2014.11.047
M3 - Review article
C2 - 25461329
AN - SCOPUS:84913582348
SN - 0223-5234
VL - 90
SP - 379
EP - 393
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
ER -