TY - JOUR
T1 - Biocidal Properties of Chitosan-Encapsulated Ternary Titanium Dioxide-Nickel Oxide-Copper Oxide Hybrid Nanomaterials Were Prepared via a Facile One-Pot Precipitation Process
AU - Vishnuvardhanaraj, Govindaraj
AU - Bharathidasan, Ganesan
AU - Tamilvedan, Dhanapal
AU - Karthikeyan, Chandrasekaran
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/12
Y1 - 2023/12
N2 - Chitosan-encapsulated ternary titanium dioxide-nickel oxide-copper oxide (CTNC) hybrid nanomaterials (HNM) were synthesised via a facile one-pot precipitation method. The synthesised chitosan-titanium dioxide-nickel oxide-copper oxide was characterised by XRD, UV, FTIR, DLS, FESEM, EDAX, and PL tested against G− (gram-negative) bacterial strains such as K. pneumonia, S. dysenteriae, E. coli, P. vulgaris, P. aeruginosa, and V. cholerae, employed by the well method. The CTNC hybrid nanomaterials exhibit a more substantial antibacterial effect against gram-negative bacteria. The MDA-MB-231 cell-line with an IC50 concentration value of 9.8 g/mL was chosen to test CTNC hybrid nanomaterials’ anticancer properties against human breast cancer cell lines. The toxicity studies of fibroblast L929 cells showed that the CTNC hybrid nanomaterials were less harmful to healthy cells. As a result, the CTNC hybrid nanomaterials can be used for biomedical and industrial applications to improve human health conditions.
AB - Chitosan-encapsulated ternary titanium dioxide-nickel oxide-copper oxide (CTNC) hybrid nanomaterials (HNM) were synthesised via a facile one-pot precipitation method. The synthesised chitosan-titanium dioxide-nickel oxide-copper oxide was characterised by XRD, UV, FTIR, DLS, FESEM, EDAX, and PL tested against G− (gram-negative) bacterial strains such as K. pneumonia, S. dysenteriae, E. coli, P. vulgaris, P. aeruginosa, and V. cholerae, employed by the well method. The CTNC hybrid nanomaterials exhibit a more substantial antibacterial effect against gram-negative bacteria. The MDA-MB-231 cell-line with an IC50 concentration value of 9.8 g/mL was chosen to test CTNC hybrid nanomaterials’ anticancer properties against human breast cancer cell lines. The toxicity studies of fibroblast L929 cells showed that the CTNC hybrid nanomaterials were less harmful to healthy cells. As a result, the CTNC hybrid nanomaterials can be used for biomedical and industrial applications to improve human health conditions.
KW - Antibacterial activity
KW - Anticancer activity
KW - Hybrid nanomaterials
KW - Ternary metal oxide
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=85166671225&partnerID=8YFLogxK
U2 - 10.1007/s12668-023-01164-4
DO - 10.1007/s12668-023-01164-4
M3 - Article
AN - SCOPUS:85166671225
SN - 2191-1630
VL - 13
SP - 1863
EP - 1869
JO - BioNanoScience
JF - BioNanoScience
IS - 4
ER -