TY - JOUR
T1 - Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications
AU - Zheng, Ting
AU - Pour Shahid Saeed Abadi, Parisa
AU - Seo, Jungmok
AU - Cha, Byung Hyun
AU - Miccoli, Beatrice
AU - Li, Yi Chen
AU - Park, Kijun
AU - Park, Sunghyun
AU - Choi, Seon Jin
AU - Bayaniahangar, Rasoul
AU - Zhang, Dongxing
AU - Lee, Soo Hong
AU - Lee, Chang Kee
AU - Khademhosseini, Ali
AU - Shin, Su Ryon
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/6/12
Y1 - 2019/6/12
N2 - Biocompatible, electrically conductive microfibers with superior mechanical properties have received a great attention due to their potential applications in various biomedical applications such as implantable medical devices, biosensors, artificial muscles, and microactuators. Here, we developed an electrically conductive and mechanically stable carbon nanotube-based microactuator with a low degradability that makes it usable for an implantable device in the body or biological environments. The microfiber was composed of hyaluronic acid (HA) hydrogel and single-wall carbon nanotubes (SWCNTs) (HA/SWCNT). HA hydrogel acts as biosurfactant and ion-conducting binder to improve the dispersion of SWCNTs resulting in enhanced electrical and mechanical properties of the hybrid microfiber. In addition, HA was crosslinked to prevent the leaking of the nanotubes from the composite. Crosslinking of HA hydrogel significantly enhances Young's modulus, the failure strain, the toughness, the stability of the electrical conductivity, and the resistance to biodegradation and creep of hybrid microfibers. The obtained crosslinked HA/SWCNT hybrid microfibers show an excellent capacitance and actuation behavior under mechanical loading with a low potential of ±1 V in a biological environment. Furthermore, the HA/SWCNT microfibers exhibit an excellent in vitro viability. Finally, the biocompatibility is shown through the resolution of an early inflammatory response in less than 3 weeks after the implantation of the microfibers in the subcutaneous tissue of mice.
AB - Biocompatible, electrically conductive microfibers with superior mechanical properties have received a great attention due to their potential applications in various biomedical applications such as implantable medical devices, biosensors, artificial muscles, and microactuators. Here, we developed an electrically conductive and mechanically stable carbon nanotube-based microactuator with a low degradability that makes it usable for an implantable device in the body or biological environments. The microfiber was composed of hyaluronic acid (HA) hydrogel and single-wall carbon nanotubes (SWCNTs) (HA/SWCNT). HA hydrogel acts as biosurfactant and ion-conducting binder to improve the dispersion of SWCNTs resulting in enhanced electrical and mechanical properties of the hybrid microfiber. In addition, HA was crosslinked to prevent the leaking of the nanotubes from the composite. Crosslinking of HA hydrogel significantly enhances Young's modulus, the failure strain, the toughness, the stability of the electrical conductivity, and the resistance to biodegradation and creep of hybrid microfibers. The obtained crosslinked HA/SWCNT hybrid microfibers show an excellent capacitance and actuation behavior under mechanical loading with a low potential of ±1 V in a biological environment. Furthermore, the HA/SWCNT microfibers exhibit an excellent in vitro viability. Finally, the biocompatibility is shown through the resolution of an early inflammatory response in less than 3 weeks after the implantation of the microfibers in the subcutaneous tissue of mice.
KW - biocompatibility
KW - conductive fiber
KW - electrochemical microactuator
KW - hyaluronic acid
KW - single-walled carbon nanotubes
UR - http://www.scopus.com/inward/record.url?scp=85066836712&partnerID=8YFLogxK
U2 - 10.1021/acsami.9b02927
DO - 10.1021/acsami.9b02927
M3 - Article
C2 - 31050404
AN - SCOPUS:85066836712
SN - 1944-8244
VL - 11
SP - 20615
EP - 20627
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 23
ER -