Biodegradable polymers for modern vaccine development

Rajendran JC Bose; Minwoo Kim; Ji Hyun Chang; Ramasamy Paulmurugan; James J. Moon; Won Gun Koh; Soo Hong Lee; Hansoo Park

doi:10.1016/j.jiec.2019.04.044

Biodegradable polymers for modern vaccine development

Rajendran JC Bose, Minwoo Kim, Ji Hyun Chang, Ramasamy Paulmurugan, James J. Moon, Won Gun Koh, Soo Hong Lee, Hansoo Park

Department of Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

Most traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy. This review summarizes the potential of biodegradable materials, including synthetic and natural polymers, for vaccine delivery. These materials are highly biocompatible and have minimal toxicity, and most biomaterial-based vaccines delivering antigens or adjuvants have been shown to improve immune response, compared to formulations consisting of the antigen alone. Therefore, these materials can be applied in modern vaccine development.

Original language	English
Pages (from-to)	12-24
Number of pages	13
Journal	Journal of Industrial and Engineering Chemistry
Volume	77
DOIs	https://doi.org/10.1016/j.jiec.2019.04.044
State	Published - 25 Sep 2019

Keywords

Adjuvant
Biocompatibility
Biodegradable polymer
Biomaterial
Vaccine delivery system

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiec.2019.04.044

Cite this

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title = "Biodegradable polymers for modern vaccine development",

abstract = "Most traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy. This review summarizes the potential of biodegradable materials, including synthetic and natural polymers, for vaccine delivery. These materials are highly biocompatible and have minimal toxicity, and most biomaterial-based vaccines delivering antigens or adjuvants have been shown to improve immune response, compared to formulations consisting of the antigen alone. Therefore, these materials can be applied in modern vaccine development.",

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AU - Bose, Rajendran JC

AU - Kim, Minwoo

AU - Chang, Ji Hyun

AU - Paulmurugan, Ramasamy

AU - Moon, James J.

AU - Koh, Won Gun

AU - Lee, Soo Hong

AU - Park, Hansoo

PY - 2019/9/25

Y1 - 2019/9/25

N2 - Most traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy. This review summarizes the potential of biodegradable materials, including synthetic and natural polymers, for vaccine delivery. These materials are highly biocompatible and have minimal toxicity, and most biomaterial-based vaccines delivering antigens or adjuvants have been shown to improve immune response, compared to formulations consisting of the antigen alone. Therefore, these materials can be applied in modern vaccine development.

AB - Most traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy. This review summarizes the potential of biodegradable materials, including synthetic and natural polymers, for vaccine delivery. These materials are highly biocompatible and have minimal toxicity, and most biomaterial-based vaccines delivering antigens or adjuvants have been shown to improve immune response, compared to formulations consisting of the antigen alone. Therefore, these materials can be applied in modern vaccine development.

KW - Adjuvant

KW - Biocompatibility

KW - Biodegradable polymer

KW - Biomaterial

KW - Vaccine delivery system

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DO - 10.1016/j.jiec.2019.04.044

M3 - Review article

AN - SCOPUS:85065986805

SN - 1226-086X

VL - 77

SP - 12

EP - 24

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Biodegradable polymers for modern vaccine development

Abstract

Keywords

UN SDGs

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